期刊
CELL HOST & MICROBE
卷 29, 期 7, 页码 1167-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2021.05.008
关键词
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资金
- Biotechnology and Biological Sciences Research Council (BBSrC) Institute Strategic Programme Gut Microbes and Health [BB/r012490/1, BBS/e/F/000Pr10355]
- EMBL
- European Research Council [669830]
- European Union's Horizon 2020 research and innovation program [948219]
- Marie Sk1odowska-Curie program [660375]
- BMBF LAMARCK [031L0181A]
- Innovation Fund Denmark [4203-00005B]
- European Research Council (ERC) [669830, 948219] Funding Source: European Research Council (ERC)
- Marie Curie Actions (MSCA) [660375] Funding Source: Marie Curie Actions (MSCA)
Human gut bacterial strains can persist for decades in individuals, families, and geographic regions, with locally successful strains of Bacteroidota showing high levels of genetic adaptation. By contrast, Firmicutes rely on weak phylogeographic patterns but strong family transmissions, likely related to sporulation. These analyses provide insights into long-term persistence of gut microbes and the implications for gut flora modulations.
Human gut bacterial strains can co-exist with their hosts for decades, but little is known about how these microbes persist and disperse, and evolve thereby. Here, we examined these processes in 5,278 adult and infant fecal metagenomes, longitudinally sampled in individuals and families. Our analyses revealed that a subset of gut species is extremely persistent in individuals, families, and geographic regions, represented often by locally successful strains of the phylum Bacteroidota. These ''tenacious'' bacteria show high levels of genetic adaptation to the human host but a high probability of loss upon antibiotic interventions. By contrast, heredipersistent bacteria, notably Firmicutes, often rely on dispersal strategies with weak phylogeographic patterns but strong family transmissions, likely related to sporulation. These analyses describe how different dispersal strategies can lead to the long-term persistence of human gut microbes with implications for gut flora modulations.
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