4.7 Review

Molecular mechanisms of cell death in neurological diseases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

NINJ1 mediates plasma membrane rupture during lytic cell death

Nobuhiko Kayagaki et al.

Summary: Plasma membrane rupture is a cataclysmic event in lytic cell death, releasing damage-associated molecular patterns to propagate the inflammatory response. NINJ1 protein plays an essential role in inducing PMR, with Ninj1-deficient macrophages showing impaired release of intracellular proteins and distinctive ballooned morphology. This study overturns the long-held belief that cell death-related PMR is a passive event, highlighting the active role of NINJ1 in mediating PMR.

NATURE (2021)

Article Biochemistry & Molecular Biology

Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines

Yulin Zhang et al.

Summary: The research identified COPZ1 as a therapeutic target candidate for GBM due to its role in dysregulating iron metabolism, leading to increased tumor grade and poor prognosis. Suppression of COPZ1 through siRNA knockdown inhibited proliferation and tumor growth of GBM cells both in vitro and in vivo, suggesting COPZ1/NCOA4/FTH1 axis as a potential novel therapeutic target for human GBM.

ONCOGENE (2021)

Article Pharmacology & Pharmacy

CuII(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

Adam Southon et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease

Maritza Onate et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Biochemistry & Molecular Biology

Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS

Taide Wang et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Biochemistry & Molecular Biology

Autophagy and disease: unanswered questions

Ying Yang et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Biochemistry & Molecular Biology

Bim contributes to the progression of Huntington's disease-associated phenotypes

Sheridan L. Roberts et al.

HUMAN MOLECULAR GENETICS (2020)

Article Biochemistry & Molecular Biology

Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition

Renxin Yi et al.

BIOSCIENCE REPORTS (2020)

Article Chemistry, Multidisciplinary

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

Vanessa A. N. Kraft et al.

ACS CENTRAL SCIENCE (2020)

Article Multidisciplinary Sciences

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Lucie Laurien et al.

NATURE COMMUNICATIONS (2020)

Article Cell Biology

Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression

Han-jie Liu et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Multidisciplinary Sciences

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Andre L. Samson et al.

NATURE COMMUNICATIONS (2020)

Review Cell Biology

Emerging connectivity of programmed cell death pathways and its physiological implications

Sammy Bedoui et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Medicine, General & Internal

Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis

Sabrina Paganoni et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Correction Neurosciences

The Iron Chelator Deferiprone Improves the Phenotype in a Mouse Model of Tauopathy (vol 77, pg 753, 2020)

Shalini S. Rao et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

Article Multidisciplinary Sciences

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

Patricia P. Yee et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

The role of necroptosis in cancer: A double-edged sword?

Xia Qin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

Review Biochemistry & Molecular Biology

The Coming Decade of Cell Death Research: Five Riddles

Douglas R. Green

Review Medicine, Research & Experimental

Inflammasomes in neuroinflammatory and neurodegenerative diseases

Sofie Voet et al.

EMBO MOLECULAR MEDICINE (2019)

Review Biochemistry & Molecular Biology

The role of necroptosis in cancer biology and therapy

Yitao Gong et al.

MOLECULAR CANCER (2019)

Review Immunology

Cell death-mediated cytokine release and its therapeutic implications

David E. Place et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Multidisciplinary Sciences

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

Article Multidisciplinary Sciences

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Mcl-1 and Bcl-xL are essential for survival of the developing nervous system

Lauren C. Fogarty et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Biochemistry & Molecular Biology

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

Jonathan P. Bernardini et al.

EMBO JOURNAL (2019)

Review Cell Biology

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Rumani Singh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Could Conservative Iron Chelation Lead to Neuroprotection in Amyotrophic Lateral Sclerosis?

Caroline Moreau et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Biochemistry & Molecular Biology

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

Francine F. S. Ke et al.

Review Neurosciences

Cell Death Mechanisms in Stroke and Novel Molecular and Cellular Treatment Options

Emine Sekerdag et al.

CURRENT NEUROPHARMACOLOGY (2018)

Article Medicine, Research & Experimental

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz Hassannia et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

News Item Biotechnology & Applied Microbiology

Microglia-targeted candidates push the Alzheimer drug

Asher Mullard

NATURE REVIEWS DRUG DISCOVERY (2018)

Review Pharmacology & Pharmacy

Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response

Sabine Hombach-Klonisch et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Article Multidisciplinary Sciences

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

Brienne A. McKenzie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Chemistry, Multidisciplinary

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

Ron Shah et al.

ACS CENTRAL SCIENCE (2018)

Review Cell Biology

Life, death and autophagy

Johnna Doherty et al.

NATURE CELL BIOLOGY (2018)

Article Medicine, Research & Experimental

Nec-1 alleviates cognitive impairment with reduction of A and tau abnormalities in APP/PS1 mice

Seung-Hoon Yang et al.

EMBO MOLECULAR MEDICINE (2017)

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Autophagy in cancer metastasis

E. E. Mowers et al.

ONCOGENE (2017)

Review Immunology

Caspase-8: regulating life and death

Bart Tummers et al.

IMMUNOLOGICAL REVIEWS (2017)

Article Biochemistry & Molecular Biology

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Q-z Tuo et al.

MOLECULAR PSYCHIATRY (2017)

Article Neurosciences

Necroptosis activation in Alzheimer's disease

Antonella Caccamo et al.

NATURE NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS

Noam D. Rudnick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

RIPK1 mediates a disease-associated microglial response in Alzheimer's disease

Dimitry Ofengeim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Cell Biology

Autophagy and Tumor Metabolism

Alec C. Kimmelman et al.

CELL METABOLISM (2017)

Article Multidisciplinary Sciences

Pore-forming activity and structural autoinhibition of the gasdermin family

Jingjin Ding et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Scott J. Dixon et al.

ACS CHEMICAL BIOLOGY (2015)

Article Medicine, Research & Experimental

Effects of Iron Ions and Iron Chelation on the Efficiency of Experimental Radiotherapy of Animals with Gliomas

S. D. Ivanov et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2015)

Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice

Masaru Kurosawa et al.

HUMAN MOLECULAR GENETICS (2015)

Article Biochemistry & Molecular Biology

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

David Devos et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Review Cell Biology

Historical landmarks of autophagy research

Yoshinori Ohsumi

CELL RESEARCH (2014)

Review Medicine, Research & Experimental

Emerging treatment strategies for glioblastoma multiforme

Steven K. Carlsson et al.

EMBO MOLECULAR MEDICINE (2014)

Article Chemistry, Multidisciplinary

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Rachid Skouta et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Review Biochemistry & Molecular Biology

Many stimuli pull the necrotic trigger, an overview

N. Vanlangenakker et al.

CELL DEATH AND DIFFERENTIATION (2012)

Article Medicine, Research & Experimental

Genetics of Parkinson's Disease

Christine Klein et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Endocrinology & Metabolism

Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI

Frances J. Northington et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2011)

Article Clinical Neurology

Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis

Shoichi Sasaki

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)

Article Medicine, General & Internal

Amyotrophic lateral sclerosis

Matthew C. Kiernan et al.

LANCET (2011)

Review Clinical Neurology

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

Laura Ferraiuolo et al.

NATURE REVIEWS NEUROLOGY (2011)

Article Medicine, Research & Experimental

Neuropathological Alterations in Alzheimer Disease

Alberto Serrano-Pozo et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)

Article Clinical Neurology

Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons

T. Ekegren et al.

ACTA NEUROLOGICA SCANDINAVICA (2010)

Review Biochemistry & Molecular Biology

Mechanisms Underlying Inflammation in Neurodegeneration

Christopher K. Glass et al.

Article Medicine, Research & Experimental

Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis

Nichole A. Reyes et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Review Chemistry, Multidisciplinary

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

Xiao-xia Dong et al.

ACTA PHARMACOLOGICA SINICA (2009)

Review Behavioral Sciences

Minocycline and neurodegenerative diseases

Hye-Sun Kim et al.

BEHAVIOURAL BRAIN RESEARCH (2009)

Review Biochemistry & Molecular Biology

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

G. Kroemer et al.

CELL DEATH AND DIFFERENTIATION (2009)

Review Cell Biology

The genetics of Parkinson's syndromes: a critical review

John Hardy et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2009)

Review Immunology

The Many Roles of FAS Receptor Signaling in the Immune System

Andreas Strasser et al.

IMMUNITY (2009)

Review Cell Biology

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

Adrienne M. Gorman

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)

Article Neurosciences

Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage

Nicole Arbour et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Multidisciplinary Sciences

Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma

Alexander H. Stegh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Neurosciences

Increased autophagy in transgenic mice with a G93A mutant SOD1 gene

Nobutoshi Morimoto et al.

BRAIN RESEARCH (2007)

Letter Biochemistry & Molecular Biology

The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis

C. Hetz et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Biochemistry & Molecular Biology

Apoptotic mechanisms in mutant LRRK2-mediated cell death

Ciro Iaccarino et al.

HUMAN MOLECULAR GENETICS (2007)

Review Multidisciplinary Sciences

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

Michael T. Lin et al.

NATURE (2006)

Review Neurosciences

ALS:: A disease of motor neurons and their nonneuronal neighbors

Sverine Boillee et al.

NEURON (2006)

Review Biochemistry & Molecular Biology

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

S. Fulda et al.

ONCOGENE (2006)

Article Clinical Neurology

Expression pattern of apoptosis-related markers in Huntington's disease

JC Vis et al.

ACTA NEUROPATHOLOGICA (2005)

Article Biochemistry & Molecular Biology

Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

Y Ohyagi et al.

FASEB JOURNAL (2005)

Article Biochemistry & Molecular Biology

Intracellular Aβ42 activates p53 promoter:: a pathway to neurodegeneration in Alzheimer's disease

Y Ohyagi et al.

FASEB JOURNAL (2004)

Article Biochemistry & Molecular Biology

Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity

DC Lu et al.

JOURNAL OF NEUROCHEMISTRY (2003)

Review Biochemistry & Molecular Biology

Keeping killers on a tight leash: transcriptional and posttranslational control of the pro-apoptotic activity of BH3-only proteins

H Puthalakath et al.

CELL DEATH AND DIFFERENTIATION (2002)

Review Biochemistry & Molecular Biology

Mechanisms of caspase activation and inhibition during apoptosis

YG Shi

MOLECULAR CELL (2002)

Review Biochemistry & Molecular Biology

Apoptotic pathways: Paper wraps stone blunts scissors

DR Green

Review Neurosciences

Mechanisms of programmed cell death in the developing brain

CY Kuan et al.

TRENDS IN NEUROSCIENCES (2000)

Article Multidisciplinary Sciences

Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model

MW Li et al.

SCIENCE (2000)