期刊
CELL COMMUNICATION AND SIGNALING
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12964-021-00762-7
关键词
Hepatitis B virus; Calcium signaling; Infection; Therapy
类别
资金
- Jiangsu Health and Family Planning Commission [Z2018017]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Calcium acts as a ubiquitous second messenger in HBV infection, elevating cytosolic Ca2+ levels through different channels and promoting viral replication. Targeting Ca2+ signaling is an effective approach for the treatment of HBV infection.
As a ubiquitous second messenger, calcium (Ca2+) can interact with numerous cellular proteins to regulate multiple physiological processes and participate in a variety of diseases, including hepatitis B virus (HBV) infection, which is a major cause of hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. In recent years, several studies have demonstrated that depends on the distinct Ca2+ channels on the plasma membrane, endoplasmic reticulum, as well as mitochondria, HBV can elevate cytosolic Ca2+ levels. Moreover, within HBV-infected cells, the activation of intracellular Ca2+ signaling contributes to viral replication via multiple molecular mechanisms. Besides, the available evidence indicates that targeting Ca2+ signaling by suitable pharmaceuticals is a potent approach for the treatment of HBV infection. In the present review, we summarized the molecular mechanisms related to the elevation of Ca2+ signaling induced by HBV to modulate viral propagation and the recent advances in Ca2+ signaling as a potential therapeutic target for HBV infection.
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