Types of nuclear localization signals and mechanisms of protein import into the nucleus

Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition, a process necessary for cargo proteins to pass the nuclear envelope through the nuclear pore complex, is facilitated by members of the importin superfamily. Here, we summarized the types of NLS, focused on the recently reported related proteins containing nuclear localization signals, and briefly summarized some mechanisms that do not depend on nuclear localization signals into the nucleus.

Automated summary

This article summarizes the types of nuclear localization signals, focuses on recently reported proteins containing such signals, and briefly outlines mechanisms for nuclear entry that do not rely on nuclear localization signals.