Where have all the Orais gone? Commentary on Orai1 channels are essential for amplification of glutamate-evoked Ca2+ signals in dendritic spines to regulate working and associative memory

Orai1 channels were reported as critical contributors to the Ca2+ signal in hippocampal neurons underlying synaptic plasticity associated with learning and memory. We discuss the results in view of conflicting other reports that stressed the roles of Orai2 channels but failed to detect functions of Orai1 channels in these neurons.

Automated summary

This study explores the critical role of Orai1 channels in hippocampal neurons, which contribute to the Ca2+ signal and synaptic plasticity associated with learning and memory. The findings contrast with previous reports emphasizing the roles of Orai2 channels and overlooking the functions of Orai1 channels in these neurons.