期刊
CELL CALCIUM
卷 96, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2021.102407
关键词
Neurovascular coupling; Functional hyperemia; TRPA1 channels; Calcium signaling; Capillary endothelium; Cerebral blood flow
类别
资金
- Totman Medical Research Trust
- European Union [666881]
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institute on Aging (NIA) [R01-NS-110656]
- National Institute of General Medical Sciences (NIGMS) [P20-GM-135007]
- National Heart, Lung, and Blood Institute (NHLBI) of the NIH [R35-HL-140027]
The study provides profound insights into how the capillary endothelial TRPA1 channel contributes to blood flow control and functional hyperemia in the brain.
The just-in time delivery of oxygen and nutrients to active brain regions to support function (functional hyperemia; FH) is mediated by not yet fully understood mechanisms collectively referred to as 'neurovascular coupling' (NVC). In a recent publication (eLife 2021) Thakore et al. provide profound mechanistic insight how the capillary endothelial transient receptor potential ankyrin 1 (TRPA1) channel contribute to blood flow control and functional hyperemia in the brain.
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