Into the spotlight: RGK proteins in skeletal muscle

The RGK (Rad, Rem, Rem2 and Gem/Kir) family of small GTPases are potent endogenous inhibitors of voltage-gated Ca2+ channels (VGCCs). While the impact of RGK proteins on cardiac physiology has been investigated extensively, much less is known regarding their influence on skeletal muscle biology. Thus, the purpose of this article is to establish a basis for future investigation into the role of RGK proteins in regulating the skeletal muscle excitation-contraction (EC) coupling complex via modulation of the L-type Ca(V)1.1 VGCC. The pathological consequences of elevated muscle RGK protein expression in Type II Diabetes, Amyotrophic Lateral Sclerosis (ALS), Duchenne's Muscular Dystrophy and traumatic nerve injury are also discussed.

Automated summary

This article discusses the impact of RGK protein family on skeletal muscle biology, specifically focusing on modulating the L-type Ca(V)1.1 VGCC to regulate skeletal muscle excitation-contraction coupling. It also discusses the pathological consequences of elevated muscle RGK protein expression in certain diseases.