期刊
CELL BIOLOGY INTERNATIONAL
卷 45, 期 12, 页码 2395-2402出版社
WILEY
DOI: 10.1002/cbin.11689
关键词
aplastic anemia; cytokines; hematopoietic stem cells; immune system; mesenchymal stromal cells; signaling pathway
类别
Aplastic anemia is an autoimmune disorder characterized by bone marrow and peripheral blood pancytopenia, with the pathogenesis remaining unclear. The disease involves impairment of both hematopoietic stem cells and mesenchymal stromal cells, leading to changes in T lymphocyte ratio and disease progression. The most common mechanism of AA is damage by the immune system, causing increased apoptosis in progenitor cells.
Aplastic anemia (AA) is an autoimmune disorder characterized by bone marrow and peripheral blood pancytopenia. Different environmental and genetical conditions could be effective in an outbreak of this disease. The exact pathogenesis of this disease, however, is still idiopathic. The present study is based on Pubmed database information (2002-2021) using the words Aplastic Anemia, Hematopoietic Stem Cells niche, Signaling pathway, Cytokines, and Immuno cells. In this disease, both hematopoietic stem cells and mesenchymal stromal cells are impaired, which is associated with impaired hematopoiesis and decreased hematopoietic cells. Inflammatory cytokines increase, which changes the ratio of T lymphocytes and leads to disease progression. In addition, the most common mechanism of AA is damage by the immune system, which leads to increased apoptosis in progenitor cells. We have shown in this review that the disease involves quantitative defects in stem cell numbers and qualitative abnormalities in the function of these cells and the activity of many different cellular and molecular factors can damage hematopoietic cells and the protective substrate of these cells in this disease.
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