Parietal epithelial cell dysfunction in crescentic glomerulonephritis

Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular crescents. While the role of the immune system has been extensively studied in relation to the development of crescents, recent findings show that parietal epithelial cells play a key role in the pathophysiology of crescent formation, even in the absence of immune modulation. This review highlights our current understanding of parietal epithelial cell biology and the reported physiological and pathological roles that these cells play in glomerular lesion formation, especially in the context of crescentic glomerulonephritis.

Automated summary

Crescentic glomerulonephritis involves rapid kidney function loss and the formation of glomerular crescents. Recent studies show that parietal epithelial cells play a crucial role in crescent formation even without immune modulation. Understanding the biology of these cells and their physiological and pathological roles in glomerular lesions, particularly in the context of crescentic glomerulonephritis, is highlighted in this review.