期刊
CELL AND TISSUE RESEARCH
卷 386, 期 2, 页码 215-226出版社
SPRINGER
DOI: 10.1007/s00441-020-03397-1
关键词
Surface acoustic wave; Tissue engineering; Acoustic-wave sensors and actuators; Microfluidics; Biomedicine; Bioengineering
类别
资金
- National Natural Science Foundation of China [31627801, 31800826]
- China Postdoctoral Science Foundation [2020M671728]
The surface acoustic wave (SAW) technique, a biocompatible, accessible, label-free, and non-invasive tool, has gained significant attention in tissue engineering for its ability to achieve precise cell sorting, manipulation, patterning, and rapid spheroid formation. Its integration into lab-on-a-chip platforms has proposed a novel approach in tissue engineering research.
Recently, the introduction of surface acoustic wave (SAW) technique for microfluidics has drawn a lot of attention. The pattern and mutual communication in cell layers, tissues, and organs play a critical role in tissue homeostasis and regeneration and may contribute to disease occurrence and progression. Tissue engineering aims to repair and regenerate damaged organs, depending on biomimetic scaffolds and advanced fabrication technology. However, traditional bioengineering synthesis approaches are time-consuming, heterogeneous, and unmanageable. It is hard to pattern cells in scaffolds effectively with no impact on cell viability and function. Here, we summarize a biocompatible, easily available, label-free, and non-invasive tool, surface acoustic wave (SAW) technique, which is getting a lot of attention in tissue engineering. SAW technique can realize accurate sorting, manipulation, and cells' pattern and rapid formation of spheroids. By integrating several SAW devices onto lab-on-a-chip platforms, tissue engineering lab-on-a-chip system was proposed. To the best of our knowledge, this is the first report to summarize the application of this novel technique in the field of tissue engineering.
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