期刊
CELL AND TISSUE RESEARCH
卷 387, 期 3, 页码 377-389出版社
SPRINGER
DOI: 10.1007/s00441-021-03486-9
关键词
Microglia; Microgliogenesis; Neurogenesis; Neural stem cell; Microglia progenitor
类别
资金
- National Institutes of Health [R15 NS096562/NS/NINDS]
- NIH HHS/United States
Physiological functions require coordination among diverse organs, tissues, and cells. Microglia, immune cells in the brain, play a critical role in both defense against harmful pathogens and cellular debris as well as in neurophysiology.
Physiological functions require coordination of processes between diverse organs, tissues, and cells. This integrative view of science has reemerged complementary to the reductionist philosophy of studying individual cell types. An integrative approach has proven particularly powerful within the field of neuroscience where, intermingled among the most numerous neural cell types of the brain, are immune cells called microglia. Microglia act as a line of defense in the CNS by phagocytizing harmful pathogens and cellular debris and by releasing a variety of factors that mediate immune responses. However, microglia are also appreciated as critical mediators of neurophysiology making them a desired target to rectify neuropathological states. The goal of this review is to discuss microglia ontogenesis, referred to as microgliogenesis, a term that encompasses the events that drive the production, differentiation, migration, and maturation of microglia and opportunities to target microglia for brain repair.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据