期刊
CELL
卷 184, 期 15, 页码 4090-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2021.05.013
关键词
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资金
- NIH/NIDCR [DE025046, DE029436, DE028561]
- NIH/NIAMS
- FONDECYT through the National Agency of Research and Development (ANID), Chile [11180389]
- Barbour Foundation
- Wellcome [WT107931/Z/15/Z]
- Lister Institute for Preventive Medicine
- Newcastle NIHR Biomedical Research Centre (BRC)
- NIDCD Division of Intramural Research/NIH [ZIC DC000086]
- Combined Technical Research Core (NIDCR) [ZIC DE000729-09]
The oral mucosa is an understudied barrier tissue rich in antigens and commensals, susceptible to periodontitis. By compiling a single-cell transcriptome atlas, researchers identified inflammatory epithelial and stromal cell populations promoting antimicrobial defenses and neutrophil recruitment. Exaggerated stromal cell responsiveness was found to enhance neutrophil and leukocyte infiltration in periodontitis, highlighting the role of tissue stroma in regulating mucosal tissue homeostasis and disease pathogenesis.
The oral mucosa remains an understudied barrier tissue. This is a site of rich exposure to antigens and commensals, and a tissue susceptible to one of the most prevalenthuman inflammatory diseases, periodontitis. To aid in understanding tissue-specific pathophysiology, we compile a single-cell transcriptome atlas of human oral mucosa in healthy individuals and patients with periodontitis. We uncover the complex cellular landscape of oral mucosal tissues and identify epithelial and stromal cell populations with inflammatory signatures that promote antimicrobial defenses and neutrophil recruitment. Our findings link exaggerated stromal cell responsiveness with enhanced neutrophil and leukocyte infiltration in periodontitis. Our work provides a resource characterizing the role of tissue stroma in regulating mucosal tissue homeostasis and disease pathogenesis.
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