期刊
CELL
卷 184, 期 19, 页码 4939-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2021.07.030
关键词
-
资金
- National Institutes of Health [U19AI135995, 3U19AI135995-03S2, UL1TR002550, U01AI151812, U01AI124302, R01AI153044, R01HG006139]
- European Research Council under the European Union's Horizon 2020 research and innovation program [725422]
- European Union [874850]
- Wellcome Trust [206298/Z/17/Z]
- Research Foundation-Flanders (Fonds voor Wetenschappelijk Onderzoek-Vlaanderen'') [G066215N, G0D5117N, G0B9317N]
- National Science Foundation Small Business Innovation Research [2027424, 1830867]
- NVIDIA Corporation
- Advanced Micro Devices, Inc.
- CDC BAA contract [75D30120C09795]
- Directorate For Engineering [1830867] Funding Source: National Science Foundation
- Dir for Tech, Innovation, & Partnerships
- Translational Impacts [2027424] Funding Source: National Science Foundation
- Div Of Industrial Innovation & Partnersh [1830867] Funding Source: National Science Foundation
The COVID-19 epidemic in the U.S. was initially undetected due to inadequate testing. New Orleans experienced an early outbreak related to Mardi Gras, with one introduction of SARS-CoV-2 leading to most of the early transmission. Genomic data showed SARS-CoV-2 was present in New Orleans before Mardi Gras, and the festival significantly accelerated transmission.
The emergence of the COVID-19 epidemic in the United States (U.S.) went largely undetected due to inadequate testing. New Orleans experienced one of the earliest and fastest accelerating outbreaks, coinciding with Mardi Gras. To gain insight into the emergence of SARS-CoV-2 in the U.S. and how large-scale events accelerate transmission, we sequenced SARS-CoV-2 genomes during the first wave of the COVID-19 epidemic in Louisiana. We show that SARS-CoV-2 in Louisiana had limited diversity compared to other U.S. states and that one introduction of SARS-CoV-2 led to almost all of the early transmission in Louisiana. By analyzing mobility and genomic data, we show that SARS-CoV-2 was already present in New Orleans before Mardi Gras, and the festival dramatically accelerated transmission. Our study provides an understanding of how superspreading during large-scale events played a key role during the early outbreak in the U.S. and can greatly accelerate epidemics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据