4.5 Article

A Multidimensional Group Testing Approach for the Reagent Optimisation of a Suzuki C-C Coupling Reaction

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CATALYSIS LETTERS
卷 152, 期 3, 页码 791-798

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SPRINGER
DOI: 10.1007/s10562-021-03670-0

关键词

Multidimensional group testing; Deconvolution; Combinatorial chemistry; Suzuki cross-coupling; High-throughput

资金

  1. National Research Foundation of South Africa [5386]
  2. University of Johannesburg

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This study utilized a multidimensional group testing approach for deconvoluting reagents in a Suzuki cross-coupling reaction, aiming to accelerate the identification of the optimal reagents. Through two deconvolution approaches, it was determined that K2CO3, ethanol, and benzyldiphenylphosphine were the optimal reagents. This approach enables faster identification of optimal reagents and greatly reduces the number of reactions required.
A multidimensional group testing approach was utilised for the deconvolution of reagents for a Suzuki cross-coupling reaction. This proof of concept aimed to accelerate the identification of the best reagents for such a reaction. Two deconvolution approaches showed that K2CO3, ethanol and benzyldiphenylphosphine were the optimal reagents. With this approach, the optimal reagents are identified faster, and the number of reactions is drastically reduced. [GRAPHICS] .

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