NAD+ metabolism and cardiometabolic health: the human evidence

Review Cardiac & Cardiovascular Systems

Caloric restriction mimetics for the treatment of cardiovascular diseases

Sebastiano Sciarretta et al.

Summary: Caloric restriction mimetics have shown potential as therapeutic agents for cardiovascular diseases by mimicking the effects of caloric restriction through activating autophagy and ameliorating cardiac function. These compounds can reduce cardiac hypertrophy and maladaptive remodelling in animal models of various cardiac diseases, and may have future clinical applications.

CARDIOVASCULAR RESEARCH (2021)

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Article Cell Biology

Nicotinamide for the treatment of heart failure with preserved ejection fraction

Mahmoud Abdellatif et al.

Summary: The study suggests that using nicotinamide to increase NAD(+) can improve cardiac dysfunction in HFpEF patients by enhancing myocardial energy metabolism and directly improving cardiomyocyte function. High intake of naturally occurring NAD(+) precursors is associated with lower blood pressure and reduced risk of cardiac mortality.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction

Dan Tong et al.

Summary: The study demonstrated through a mouse model that HFpEF is associated with myocardial mitochondrial dysfunction, and NAD(+) supplementation is considered a promising therapeutic approach.

CIRCULATION RESEARCH (2021)

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Article Multidisciplinary Sciences

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Mihoko Yoshino et al.

Summary: The study demonstrates that NMN supplementation can enhance insulin sensitivity, insulin signaling, and remodeling in women with prediabetes who are overweight or obese, improving their metabolic function.

SCIENCE (2021)

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Article Cardiac & Cardiovascular Systems