期刊
CARBOHYDRATE POLYMERS
卷 264, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.117965
关键词
Chitosan-based hydrogel; Hemostasis; Biodistribution; Biodegradability
资金
- National Key R&D Program of China [2018YFC0311102]
- Independent Innovation Program of Qingdao [18-1-1-92-nsh]
In this study, a degradable chitosan-based hydrogel cross-linked by oxidized hyaluronic acid was developed, showing excellent biodegradability and biocompatibility. The hydrogel exhibited good hemostatic performance in rat liver resection injury and was rapidly absorbed by the body without significant accumulation, indicating its potential as a promising hemostatic hydrogel for controlling bleeding.
Hemostasis is of great significance regardless of the smooth operation or postoperative recovery. Therefore, it is urgent to develop a hemostatic material with excellent biodegradability and biocompatibility. It is well known that both carboxymethyl chitosan and hyaluronic acid with biodegradability and biocompatibility have wound healing promoting property. Here, a degradable chitosan-based hydrogel was prepared based on carboxymethyl chitosan and cross-linked by oxidized hyaluronic acid. The hemostatic performance of the hydrogel in rat liver resection injury was evaluated which results showed that the hydrogel exhibited comparable hemostatic properties compared with Fibrin Sealant. In addition, the hydrogel proved to be rapidly absorbed by the body without significant accumulation in vivo, demonstrating good biodegradability and biocompatibility. The overall results suggested the hydrogel will be a promising hemostatic hydrogel for controlling bleeding.
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