期刊
CARBOHYDRATE POLYMERS
卷 261, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.117847
关键词
Mesoporous silica; Layer by layer self-assembly; PLO; Lentinan; Anti-tumour
资金
- National marine economic innovation and development project [16PYY007SF17]
- Subsidized Project for Postgraduates' Innovative Fund in Scientific Research of Huaqiao University
Surface functionalization of mesoporous silica nanoparticles with natural polyelectrolyte multilayers enhanced biocompatibility, rough surface improved cytocompatibility, hemocompatibility, and histocompatibility, high loading and sustained release of doxorubicin exhibited significant anti-proliferative efficiency. The layer-by-layer self-assembled nanoparticles based on MSNs coated with PLO/LC have great potential as a drug chemotherapeutic platform and delivery technique for future human cervical cancer therapy.
Surface functionalization of mesoporous silica nanoparticles (MSNs) has been proposed as an efficient strategy for enhancing the biocompatibility and efficiency of an MSN-based carrier platform. Herein, natural polyelectrolyte multilayers composed of poly-L-ornithine (PLO) and carboxymethyl lentinan (LC) were coated on the surface of MSNs through a layer-by-layer (LbL) self-assembly technique, and were characterized by ?-potential, FTIR, 13C NMR, SEM, TEM, XRD, and TG. The prepared carrier presented alternating positive and negative potentials when coated with the polyelectrolytes, and the surface of MSN-PLO/LC was rougher compared to the naked MSNs. The biocompatibility tests, including cytocompatibility, hemocompatibility, and histocompatibility, showed that MSNs biocompatibility could be improved by modifying LC. A high loading and sustained release drug delivery system was constructed after loading doxorubicin (DOX) into the prepared MSN-PLO/LC, which exhibited significant anti-proliferative efficiency in human cervical cancer cell lines (Hela). Therefore, the PLO/LC LbL NPs (layer-by-layer self-assembled nanoparticles coated with PLO/LC layers) based on MSNs, which is easily prepared by electrostatic interactions, can be considered a promising drug chemotherapeutic platform and delivery technique for future human cervical cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据