4.7 Review

Holothurian fucosylated chondroitin sulfates and their potential benefits for human health: Structures and biological activities

期刊

CARBOHYDRATE POLYMERS
卷 275, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118691

关键词

Sea cucumber; Fucosylated chondroitin sulfate; Metabolic syndrome; Gut microbiota; Structure-activity relationship

资金

  1. Guangdong Province Zhujiang Talent Program [2019ZT08H476]
  2. Shenzhen Science and Technology Program [KQTD20180412181334790]
  3. Innovation Team Project of Universities in Guangdong Province [2020KCXTD023]

向作者/读者索取更多资源

Fucosylated chondroitin sulfates (FCS) are a type of sulfated polysaccharide found exclusively in the body wall of sea cucumber, with potential benefits in preventing metabolic syndromes and other diseases. Studies suggest that the positive effects of FCS may be achieved by modulating gut microbiota composition.
Fucosylated chondroitin sulfates (FCS) are a sulfated polysaccharide exclusively existing in the body wall of sea cucumber. FCS possesses a mammalian chondroitin sulfate like backbone, namely repeating disaccharides units composed of GlcA and GalNAc, with fucosyl branches linked to GlcA and/or GalNAc residues. It is found that FCS can prevent unhealthy dietary pattern-induced metabolic syndromes, including insulin resistance and B-cell function improvement, anti-inflammation, anti-hyperlipidemia, and anti-adipogenesis. Further studies show that those activities of FCS might be achieved through positively modulating gut microbiota composition. Besides, FCS also show therapeutic efficacy in cancer, HIV infection, and side effects of cyclophosphamide. Furthermore, bioactivities of FCS are closely affected by their molecular weights, sulfation pattern of the fucosyl branches, and chain conformations. This review summarizes the recent 20 years studies to provide references for the future studies and applications of FCS in functional foods or drugs.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据