期刊
CARBOHYDRATE POLYMERS
卷 264, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.117990
关键词
Electrospinning; Probiotic encapsulation; Cellulose acetate; Polyvinyl alcohol; Composite fibers; Simulated gastrointestinal system
资金
- Scientific and Technological Research Council of Turkey (TUBITAK) [118O860]
Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers were fabricated via angled dual-nozzle electrospinning for encapsulating probiotics with enhanced gastrointestinal stability. CA improved bacterial stability under gastric conditions while PVA provided protection during the electrospinning process. Encapsulated Escherichia coli strain Nissle 1917 (EcN) cells showed increased viability compared to free cells, demonstrating the potential of multi-nozzle electrospinning for probiotic encapsulation.
Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability. In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process. Scanning electron microscopy images revealed that EcN was successfully encapsulated within the hybrid fibers. In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers. Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据