期刊
CARBOHYDRATE POLYMERS
卷 264, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118015
关键词
Hyaluronic acid; Biosynthesis mechanism; Strain breeding; Synthetic biology; Microbial fermentation
资金
- National Natural Science Foundation of China [21978116]
- National First-class discipline Program of Light Industry Technology and Engineering [LITE201818]
- Ningxia Hui Autonomous Region Key Research & Development Plan [2019BCH01002]
- Fundamental Research Funds for the Central Universities [JUSRP22047]
Hyaluronic acid (HA) is widely used in cosmetic, medical, and clinical applications due to its outstanding properties, and microbial fermentation has become an economical and sustainable alternative for HA production. Current research focuses on increasing carbon flux into HA biosynthesis and regulating molecular weight for improved synthesis efficiency.
Owing to its outstanding water-retention ability, viscoelasticity, biocompatibility and non-immunogenicity, Hyaluronic acid (HA), a natural linear polymer alternating linked by D-glucuronic acid and N-acetylglucosamine, has been widely employed in cosmetic, medical and clinical applications. With the development of synthetic biology and bioprocessing optimization, HA production via microbial fermentation is an economical and sustainable alternative over traditional animal extraction methods. Indeed, recently Streptococci and other recombinant systems for HA synthesis has received increasing interests due to its technical advantages. This review summarizes the production of HA by microorganisms and demonstrates its synthesis mechanism, focusing on the current status in various production systems, as well as common synthetic biology strategies include driving more carbon flux into HA biosynthesis and regulating the molecular weight (MW), and finally discusses the major challenges and prospects.
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