Enhanced skin adhesive property of α-cyclodextrin/nonanyl group-modified poly(vinyl alcohol) inclusion complex film

For skin contact medical devices, realizing a strong contact with skin is essential to precisely detect human biological information and enable human-machine interaction. In this study, we aimed to fabricate and characterize an inclusion complex film (ICF) for skin adhesion using ?-cyclodextrin (?-CD) and nonanyl groupmodified PVA (C9-PVA) under wet conditions. Based on the water insolubility of C9-PVA and the inclusion ability of ?-CD for alkyl groups, ?-CD/C9-PVA ICF was prepared. Among the prepared ICFs, ?-CD/2.5C9-PVA (w/ w = 0.5) ICF showed the highest bonding strength and T-peeling strength to porcine skin. Furthermore, ?-CD/ 2.5C9-PVA (w/w = 0.5) ICF had better water vapor transmission rate than that of commercial tapes. In addition, the ion permeability test revealed that ?-CD/2.5C9-PVA (w/w = 0.5) ICF exhibited excellent Na and Cl ion permeability. These results demonstrated that the multi-functional ?-CD/2.5C9-PVA (w/w = 0.5) ICF can be a promising adhesive for skin contact medical devices.

Automated summary

This study successfully fabricated an inclusion complex film containing β-cyclodextrin and nonanyl group-modified PVA, showing good water vapor transmission rate and ion permeability, making it suitable for adhesive use in skin contact medical devices.