期刊
CANCER LETTERS
卷 515, 期 -, 页码 63-72出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2021.05.001
关键词
Resveratrol; Cancer treatment; Pharmacokinetics; Pharmacodynamics; Toxicity
类别
资金
- National Natural Science Foundation of China [81772223]
- National Medical Research Council, Singapore [NMRC/CSASI/0006/2016, NMRC/CG/M005/2017_NCIS]
- NCIS [NUHSRO/2020/122/MSC/07/Cancer]
- NUS Cancer Program Seed Funding Grants [NUHSRO/2020/122/MSC/07/Cancer]
Despite its potential anticancer effects, resveratrol faces obstacles in clinical translation due to poor pharmacokinetics, low potency, and nephrotoxicity in certain patients. New strategies to enhance its bioavailability and develop more potent analogues are proposed to overcome these challenges and advance resveratrol in cancer therapy.
Resveratrol (3,4',5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of preclinical studies on the anticancer activity of resveratrol, little progress has been made in translational research and clinical trials. Most studies have focused on its anticancer effects, cellular mechanisms, and signal transduction pathways in vitro and in vivo. In this review, we aimed to discern the causes that prevent resveratrol from being used in cancer treatment. Among the various limitations, poor pharmacokinetics and low potency seem to be the two main bottlenecks of resveratrol. In addition, resveratrolinduced nephrotoxicity in multiple myeloma patients hinders its further development as an anticancer drug. New insights and strategies have been proposed to accelerate the conversion of resveratrol from bench to bedside. In the interim, the most promising approach is to enhance the bioavailability of resveratrol with new formulations. Alternatively, more potent analogues of resveratrol could be developed to augment its anticancer potency. Given all the gaps mentioned, much work remains to be done. However, if remarkable progress can be made, resveratrol may finally be used for cancer therapy.
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