期刊
CANCER LETTERS
卷 509, 期 -, 页码 81-88出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2021.04.002
关键词
Long-non-coding RNAs; microRNAs; Sponging; Cancer stem cells; Epithelial-mesenchymal transition
类别
资金
- Dalhousie Medical Research Foundation (DMRF)
- Canadian Institutes of Health Research (CIHR) [PJT 162313]
- Genomics in Medicine scholarships from the DMRF
- Cancer Research Training Program (CRTP) scholarships through the Beatrice Hunter Cancer Research Institute (BHCRI)
- Terry Fox Research Institute
- Research Nova Scotia
- Dalhousie University's Faculty of Medicine
- CIHR [PJT 162313]
Studies have shown that long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play crucial regulatory roles in the pathogenesis of breast cancer, forming complex regulatory networks of post-transcriptional gene regulation. Depending on specific lncRNA/miRNA interactions, the lncRNA-miRNA axis can have either tumor suppressor or oncogenic effects, making it important for determining therapeutic targets.
Therapeutic effectiveness in breast cancer can be limited by the underlying mechanisms of pathogenesis, including epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs) and drug resistance. Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are master regulators of gene expression and are functionally important mediators in these mechanisms of pathogenesis. Intricate crosstalks between these non-coding RNAs form complex regulatory networks of post-transcriptional gene regulation. Depending on the specific lncRNA/miRNA interaction, the lncRNA-miRNA axis can have tumor suppressor or oncogenic effects, thus defining the lncRNA-miRNA axis is important for determining targetability. Herein, we summarize the current literature describing lncRNA-miRNA interactions that are critical in the molecular mechanisms that regulate EMT, CSCs and drug resistance in breast cancer. Further, we review both the well-studied and potential novel mechanisms of lncRNA-miRNA interactions in breast cancer.
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