期刊
CANCER LETTERS
卷 511, 期 -, 页码 1-14出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2021.04.012
关键词
Chemokines; Chemokine receptor; Colorectal cancer; Dendritic cells; Nuclear factor-kappa B
类别
资金
- National Natural Science Foundation of China [81902852, 81502548]
- Natural Science Foundation of Hubei Provincial Department of Education [D20202101]
- Foundation of Health Commission of Hubei Province [WJ2019M053]
- China Postdoctoral Science Foundation [2020M670220]
- Biomedical Research Foundation
- Hubei University of Medicine [HBMUPI201809]
- Faculty Development Grants from Hubei University of Medicine [2018QDJZR06]
- Innovative Research Program for Graduates of Hubei University of Medicine [YC2020005]
This study revealed that the inhibition of CXCL13 in colorectal cancer has a mitigating effect on disease progression by promoting intestinal tumorigenesis through the activation of the AKT signaling pathway. Intestinal microbiota translocation drives CXCL13 production in dendritic cells through the activation of NF-kappa B signaling. Inhibition of microbiota translocation reduces CXCL13 production and ameliorates intestinal tumorigenesis.
The excessive release of proinflammatory chemokines promotes cell proliferation and tumor growth in colorectal cancer. However, their regulatory functions and molecular pathogenesis have not been well elucidated. Here, we observed the upregulation of chemokine (C-X-C motif) ligand 13 (CXCL13) in human colorectal cancers and mouse intestinal tumors. Both CXCL13 deficiency and blockade of CXCL13 signaling ameliorated disease progression. CXCL13 promoted intestinal tumorigenesis through the activation of the AKT signaling pathway in a CX-C chemokine receptor type 5 (CXCR5)-dependent manner. Intestinal microbiota translocation drove CXCL13 production in dendritic cells through the activation of NF-kappa B signaling. Inhibition of microbiota translocation decreased CXCL13 production and ameliorated intestinal tumorigenesis. Together, the results of this study identify a role for the CXCL13-CXCR5 axis is involved in the crosstalk between chemokines and cell growth during the development of intestinal tumorigenesis, which also provides a therapeutic strategy for targeting CXCL13/CXCR5 in the future clinical treatment of intestinal tumors.
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