期刊
CANCER EPIDEMIOLOGY
卷 73, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.canep.2021.101973
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资金
- Utah Cancer Registry - National Cancer Institute's SEER Program [HHSN261201800016I]
- US Center for Disease Control and Prevention's National Program of Cancer Registries [NU58DP006320001]
- University of Utah
- Huntsman Cancer Foundation
- Huntsman Cancer Institute Cancer Center Support grant from the National Cancer Institute [P30 CA42014]
Research has shown that first- and second-degree relatives of early-onset CRC cases have elevated risks of developing early-onset CRC, with respective RRs of 6.0 and 3.1. Family history contributes to non-syndromic early-onset CRC, and the affected location may not necessarily be similar to that of the relatives.
Introduction: Family history is a risk factor for colorectal cancer (CRC), however whether family history also contributes to non-syndromic early-onset CRC is unknown. Methods: We estimated risk to first-, second-, and third-degree relatives of early-onset CRC cases in the Utah Pedigree Database. Results: We observed elevated risks beyond RR = 2.0 for early-onset CRC among first- and second-degree relatives of early-onset CRC cases, with RRs of 6.0 and 3.1, respectively. Discussion: Relatives of early-onset CRC cases are at higher risk of both early-onset CRC and CRC at any age, and the location is not necessarily similar to the affected relative.
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