期刊
CANCER CELL INTERNATIONAL
卷 21, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12935-021-01988-8
关键词
Long noncoding RNA 261; Biomarker; Human cancers; Biological function; Therapeutic target
类别
资金
- National Natural Science Foundation of China [81902832]
- Youth Talent Lifting Project of Henan Province [2021HYTP059]
- Key Scientific Research Project of Henan Higher Education Institutions of China [21A320026]
LINC00261, a recently discovered long intergenic non-protein coding RNA, is over-expressed in various human malignancies and functions as a tumor suppressor by regulating biological processes in cancer cells. Its up-regulation is closely correlated with favorable prognoses and clinical characteristics. This lncRNA shows promising prospects as both a biomarker and therapeutic target in tumor development.
Long noncoding RNAs (lncRNAs), are transcripts longer than 200 nucleotides that are considered to be vital regulators of many cellular processes, particularly in tumorigenesis and cancer progression. long intergenic non-protein coding RNA 261 (LINC00261), a recently discovered lncRNA, is abnormally expressed in a variety of human malignancies, including pancreatic cancer, gastric cancer, colorectal cancer, lung cancer, hepatocellular carcinoma, breast cancer, laryngeal carcinoma, endometrial carcinoma, esophageal cancer, prostate cancer, choriocarcinoma, and cholangiocarcinoma. LINC00261 mainly functions as a tumor suppressor that regulates a variety of biological processes in the above-mentioned cancers, such as cell proliferation, apoptosis, motility, chemoresistance, and tumorigenesis. In addition, the up-regulation of LINC00261 is closely correlated with both favorable prognoses and many clinical characteristics. In the present review, we summarize recent research documenting the expression and biological mechanisms of LINC00261 in tumor development. These findings suggest that LINC00261, as a tumor suppressor, has bright prospects both as a biomarker and a therapeutic target.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据