期刊
BULLETIN OF MATHEMATICAL BIOLOGY
卷 83, 期 9, 页码 -出版社
SPRINGER
DOI: 10.1007/s11538-021-00926-z
关键词
Efferocytosis; Cholesterol; Asymptotic analysis
资金
- Australian Research Council [DP160104685, DP200102071]
- Australian Research Council [DP200102071] Funding Source: Australian Research Council
The development of atherosclerotic plaques and their impact on heart attacks and strokes are complex processes that involve lipid dynamics and macrophage behavior. The proposed ODE model explores the dynamics of lipids and macrophages in plaque formation.
Atherosclerotic plaques develop over a long time and can cause heart attacks and strokes. There are no simple mathematical models that capture the different timescales of rapid macrophage and lipid dynamics and slow plaque growth. We propose a simple ODE model for lipid dynamics that includes macrophage preference for ingesting apoptotic material and modified low-density lipoproteins (modLDL) over ingesting necrotic material. We use multiple timescale analysis to show that if the necrosis rate is small then the necrotic core in the model plaque may continue to develop slowly even when the lipid levels in plaque macrophages, apoptotic material and modLDL appear to have reached equilibrium. We use the model to explore the effect of macrophage emigration, apoptotic cell necrosis, total rate of macrophage phagocytosis and modLDL influx into the plaque on plaque lipid accumulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据