期刊
BULLETIN OF MATERIALS SCIENCE
卷 44, 期 2, 页码 -出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12034-021-02463-w
关键词
Electrospinning; triple layer yarn; nanofibrous hollow structure; vascular graft
In this study, vascular scaffolds with a multi-layered structure were fabricated using electrospinning, allowing human fibroblast cells to adhere and proliferate appropriately on the surface. The prepared vascular graft demonstrated non-hemolytic properties and proper mechanical characteristics for potential applications.
In this study, vascular scaffolds were fabricated through a facile and modified method using an electrospinning procedure. For fabrication of scaffolds, at first, a three-layered nanofibrous structure comprising of polyvinyl alcohol (PVA) multifilament, PVA nanofibres and electrospun PLA fibres, respectively, as the core, middle and outer layers were produced. Then, the hollow PLA nanofibrous structure was obtained after elimination of the middle layer in water and extraction of the core part. The fabricated structures illustrated PLA nanofibres with diameters in the range of 100 to 350 nm. Fourier transform infrared spectroscopy analysis confirmed that the PLA structure remained intact during fabrication procedure of the hollow vascular grafts. The results of cell culture and cell attachment assays showed that human fibroblast cells could adhere and proliferate appropriately on the designed nanofibrous scaffold. Moreover, the hemolysis assay proved that the prepared vascular graft was non-hemolytic. The electrospun structures also exhibited proper mechanical characteristics for the considered application.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据