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The impact of COVID-19 on pregnancy and therapeutic drug development

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MZe786, a hydrogen sulfide-releasing aspirin prevents preeclampsia in heme oxygenase-1 haplodeficient pregnancy under high soluble flt-1 environment

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Summary: Preeclampsia is a common and serious complication affecting millions of pregnant women worldwide. This study found that a novel H2S-releasing aspirin can ameliorate preeclampsia by reducing hypertension and renal damage through possibly stimulating antioxidant genes, improving fetal outcomes compared to aspirin alone.

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M. J. Joyner et al.

Summary: This study found that higher anti-SARS-CoV-2 IgG antibody levels in convalescent plasma were associated with a lower risk of death among patients hospitalized with Covid-19 who were not receiving mechanical ventilation. The association between antibody levels and mortality risk was moderated by mechanical ventilation status, with no significant effect seen in patients who had already received ventilation.

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Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19

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Inclusion of pregnant women in COVID-19 treatment trials: a review and global call to action

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Summary: Despite the surge in COVID-19 treatment studies, a consistent proportion continue to exclude pregnant women, with many treatments under evaluation having low or no safety concerns during pregnancy. Urgent inclusion of pregnant women in clinical treatment trials is needed to identify effective COVID-19 treatments for this population.

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Hydrogen sulfide releasing molecule MZe786 inhibits soluble Flt-1 and prevents preeclampsia in a refined RUPP mouse model

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Summary: An imbalanced angiogenic growth factors and poor utero-placental perfusion are strongly correlated with preeclampsia. A refined RUPP model in C57B1/6 J mice was developed to test the efficacy of MZe786 as a potential inhibitor of soluble Flt-1 for preeclampsia therapy. The study demonstrated that MZe786 treatment successfully prevented the development of preeclampsia by reducing maternal MAP and kidney nitrotyrosine staining, and improving fetal outcomes.

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Non-viral COVID-19 vaccine delivery systems

Kyung Soo Park et al.

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Coronavirus disease 2019 infection and hypertensive disorders of pregnancy

Joshua I. Rosenbloom et al.

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Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19)

Torri D. Metz et al.

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E. Mullins et al.

Summary: This study analyzed data from two registries in the UK and USA regarding pregnant women with SARS-CoV-2 infection. The results showed a higher rate of preterm delivery than historical and contemporaneous national data, and rates of stillbirth, extreme preterm delivery, and neonatal infection were comparable to historical and contemporaneous data.

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Elisabeth Mahase

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Dustin D. Flannery et al.

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Nicola Vousden et al.

Summary: The study identified factors that increase the risk of symptomatic and asymptomatic SARS-CoV-2 infection in pregnancy. Clinicians can be reassured that the majority of women do not experience severe complications of SARS-CoV-2 in pregnancy. Cesarean birth rates and neonatal unit admission rates were increased for pregnant women with symptomatic and asymptomatic SARS-CoV-2. The risks of stillbirth or neonatal death were not significantly increased.

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Disease severity, pregnancy outcomes, and maternal deaths among pregnant patients with severe acute respiratory syndrome coronavirus 2 infection in Washington State

Erica M. Lokken et al.

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