相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures
Tian Hua et al.
CELL (2020)
Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex
Changrui Xing et al.
CELL (2020)
The therapeutic potential of second and third generation CB1R antagonists
Resat Cinar et al.
PHARMACOLOGY & THERAPEUTICS (2020)
Cannabinoids and Cannabinoid Receptors: The Story so Far
Fred Shahbazi et al.
ISCIENCE (2020)
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
Stephen P. H. Alexander et al.
BRITISH JOURNAL OF PHARMACOLOGY (2019)
Allosteric Modulation of Cannabinoid Receptor 1-Current Challenges and Future Opportunities
Szymon Hryhorowicz et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Structure of an allosteric modulator bound to the CB1 cannabinoid receptor
Zhenhua Shao et al.
NATURE CHEMICAL BIOLOGY (2019)
Crystal Structure of the Human Cannabinoid Receptor CB2
Xiaoting Li et al.
CELL (2019)
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
Kaavya Krishna Kumar et al.
CELL (2019)
PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?
Terry Kenakin et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2018)
Crystal structures of agonist-bound human cannabinoid receptor CB1
Tian Hua et al.
NATURE (2017)
Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development
Benjamin M. Ford et al.
PHARMACOLOGICAL RESEARCH (2017)
Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease
Debra A. Kendall et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2017)
Crystal Structure of the Human Cannabinoid Receptor CB1
Tian Hua et al.
CELL (2016)
High-resolution crystal structure of the human CB1 cannabinoid receptor
Zhenhua Shao et al.
NATURE (2016)
Adverse Effects of Synthetic Cannabinoids: Management of Acute Toxicity and Withdrawal
Ziva D. Cooper
CURRENT PSYCHIATRY REPORTS (2016)
Allosteric Modulators of the CB1 Cannabinoid Receptor: A Structural Update Review
Paula Morales et al.
CANNABIS AND CANNABINOID RESEARCH (2016)
Endocannabinoid System: A Multi-Facet Therapeutic Target
Rimplejeet Kaur et al.
CURRENT CLINICAL PHARMACOLOGY (2016)
The endocannabinoid system in guarding against fear, anxiety and stress
Beat Lutz et al.
NATURE REVIEWS NEUROSCIENCE (2015)
Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1
Jonathan F. Fay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments
Mariano Stornaiuolo et al.
SCIENTIFIC REPORTS (2015)
Real-time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action
Erin E. Cawston et al.
BRITISH JOURNAL OF PHARMACOLOGY (2013)
Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)
Kwang H. Ahn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
CB1 Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity
Gemma L. Baillie et al.
MOLECULAR PHARMACOLOGY (2013)
Probing the Interaction of SR141716A with the CB1 Receptor
Joong-Youn Shim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
A Key Agonist-induced Conformational Change in the Cannabinoid Receptor CB1 Is Blocked by the Allosteric Ligand Org 27569
Jonathan F. Fay et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities
Roger G. Pertwee
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2012)
Crystal structure of the β2 adrenergic receptor-Gs protein complex
Soren G. F. Rasmussen et al.
NATURE (2011)
A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents
N. L. Cluny et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
Joseph Tam et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
P. Jeffrey Conn et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective Agonists
John C. Ashton et al.
CURRENT MEDICINAL CHEMISTRY (2008)
Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist
Linus S. Lin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration
John C. Ashton et al.
CURRENT NEUROPHARMACOLOGY (2007)
Cannabinoid receptors as therapeutic targets
Spiro Pavlopoulos et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Allosteric modulation of the cannabinoid CB1 receptor
MR Price et al.
MOLECULAR PHARMACOLOGY (2005)
Identification and functional characterization of brainstem cannabinoid CB2 receptors
MD Van Sickle et al.
SCIENCE (2005)
Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons
J Guo et al.
MOLECULAR PHARMACOLOGY (2004)
Cannabinoid physiology and pharmacology: 30 years of progress
AC Howlett et al.
NEUROPHARMACOLOGY (2004)
Structural mimicry in class A G protein-coupled receptor rotamer toggle switches -: The importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation
SD McAllister et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
International Union of Pharmacology. XXVII. Classification of cannabinoid receptors
AC Howlett et al.
PHARMACOLOGICAL REVIEWS (2002)