Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment

This review considers the similarities and differences between the physiological systems regulated by gut-derived and neuronally produced glucagon-like peptide 1 (GLP-1). It addresses the questions of whether peripheral and central GLP-1 sources constitute separate, linked or redundant systems and whether the brain GLP-1 system consists of disparate sections or is a homogenous entity. This review also explores the implications of the answers to these questions for the use of GLP-1 receptor agonists as anti-obesity drugs.

Automated summary

This review examines the similarities and differences between physiological systems regulated by gut-derived and neuronally produced GLP-1, discussing whether peripheral and central sources of GLP-1 are separate, linked, or redundant systems, as well as the heterogeneity or homogeneity of the brain GLP-1 system, and the implications for using GLP-1 receptor agonists as anti-obesity drugs.