期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 179, 期 17, 页码 4265-4280出版社
WILEY
DOI: 10.1111/bph.15613
关键词
addiction; alcohol; cognitive biases; dopamine; reinforcement sensitivity; serotonin
资金
- Narodowe Centrum Nauki [2018/31/B/NZ7/03690]
- Maj Institute of Pharmacology Polish Academy of Sciences
Alcohol use disorder is a common yet poorly treated psychiatric condition, with reinforcement-based cognitive biases playing a key role in its development and treatment. Recent preclinical research offers new opportunities to understand the role of reinforcement sensitivity and RBCBs in various aspects of AUD.
Alcohol use disorder (AUD) is one of the most common, but still poorly treated, psychiatric conditions. Developing new treatments requires a better understanding of the aetiology of symptoms and evaluation of novel therapeutic targets in preclinical studies. Recent developments in our understanding of the reinforcement-based cognitive biases (RBCBs) that contribute to the development of AUD and its treatment offer new opportunities for both clinical and preclinical research. In this review, we first briefly describe psychological and cognitive theories that involve various aspects of reinforcement sensitivity in the development, maintenance, and recurrence of alcohol addiction. Furthermore, in separate sections, we describe studies investigating RBCBs and their neural, neurochemical, and pharmacological correlates, and we discuss possible interactions between RBCBs and trajectories of AUD. Finally, we describe how recent translational studies using state-of-the-art animal models can facilitate our understanding of the role of reinforcement sensitivity and RBCBs in various aspects of AUD.
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