4.4 Article

Study on association between height, weight, iodine supplementation and thyroid volume

期刊

BRITISH JOURNAL OF NUTRITION
卷 127, 期 9, 页码 1358-1366

出版社

CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114521002622

关键词

Iodine; Height; Weight; Iodised salt; Thyroid volume

资金

  1. National natural science foundation [NSFC81337730]

向作者/读者索取更多资源

The policy of Universal Salt Iodisation (USI) helps reduce thyroid volume, but may mask the impact of height and weight on TVOL. Factors like age, weight, and salt iodine significantly influence TVOL.
The policy of Universal Salt Iodisation (USI) could reduce population's thyroid volume (TVOL) in iodine deficiency areas. Conversely, the improved growth and developmental status of children might increase the TVOL accordingly. Whether the decreased TVOL by USI conceals the increase effect of height and weight on TVOL is unclear. The aim of this study was to analyse the association between height, weight, iodine supplementation and TVOL. Five national Iodine Deficiency Disorder surveys were matched into four pairs according to the purpose of analysis. County-level data of both detected by paired surveys were incorporated; 1:1 random pairing method was used to match counties or individuals. The difference of TVOL between different height, weight, different iodine supplementation measures groups and the association between TVOL and them were studied. The mean height and weight of children aged 8-10 years increased from 129 center dot 9 cm and 26 center dot 9 kg in 2002 to 136 center dot 2 cm and 32 center dot 1 kg in 2019, while the median TVOL decreased from 3 center dot 10 ml to 2 center dot 61 ml. Iodine supplementation measures can affect TVOL; after excluding iodine effects, the median TVOL was increased with the height and weight. On the other side, after excluding the influence of height and weight, the median TVOL remained decreased. Only age, weight and salt iodine were significantly associated with TVOL in multiple linear models. Development of height and weight in children is the evidence of improved nutrition. The decreased TVOL caused by iodised salt measures conceals the increase effect of height and weight on TVOL. Age, weight and salt iodine affect TVOL significantly.

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