期刊
EXPERIMENTAL NEUROLOGY
卷 275, 期 -, 页码 353-366出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2015.05.019
关键词
Traumatic cerebral vascular injury (TCVI); Traumatic brain injury (TBI); Neurovascular unit (NVU); Cerebrovascular reactivity (CVRx); Cerebral microvasculature; Microvascular injury; Cerebral blood flow (CBF); Controlled cortical impact (CCI); Fluid percussion injury (FPI); Chronic traumatic encephalopathy (CTE); Hypercapnia; Single photon emission computed tomography (SPECT); MRI-arterial spin labeling (MRI-ASL); Susceptibility-weighted imaging (SWI); Mild TBI(mTBI); Transcranial Doppler (TCD); Functional Near InfraRed Spectroscopy (fNIRS); Hypercapnia
资金
- Center for Neuroscience and Regenerative Medicine
- Chronic Effects of Neurotrauma Consortium
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [ZIANS003138] Funding Source: NIH RePORTER
Traumatic cerebral vascular injury (TCVI) is a very frequent, if not universal, feature after traumatic brain injury (TBI). It is likely responsible, at least in part, for functional deficits and TBI-related chronic disability. Because there are multiple pharmacologic and non-pharmacologic therapies that promote vascular health, TCVI is an attractive target for therapeutic intervention after TBI. The cerebral microvasculature is a component of the neurovascular unit (NVU) coupling neuronal metabolism with local cerebral blood flow. The NVU participates in the pathogenesis of TBI, either directly from physical trauma or as part of the cascade of secondary injury that occurs after TBI. Pathologically, there is extensive cerebral microvascular injury in humans and experimental animal, identified with either conventional light microscopy or ultrastructural examination. It is seen in acute and chronic TB!, and even described in chronic traumatic encephalopathy (CTE). Non-invasive, physiologic measures of cerebral microvascular function show dysfunction after TBI in humans and experimental animal models of TBI. These include imaging sequences (MRI-ASL), Transcranial Doppler (TCD), and Near InfraRed Spectroscopy (NIRS). Understanding the pathophysiology of TCVI, a relatively under-studied component of TBI, has promise for the development of novel therapies for TBI. Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据