期刊
EXPERIMENTAL NEUROLOGY
卷 275, 期 -, 页码 367-380出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2015.05.024
关键词
Preclinical testing; Clinical trials; Inflammatory mediators; Histology; Brain function
资金
- National Institute of Neurological Diseases and Stroke [RO1 NS076693]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS076693] Funding Source: NIH RePORTER
Traumatic brain injury rapidly induces inflammation. This inflammation is produced both by endogenous brain cells and circulating inflammatory cells that enter from the brain. Together they drive the inflammatory response through a wide variety of bioactive lipids, cytokines and chemokines. A large number of drugs with anti-inflammatory action have been tested in both preclinical studies and in clinical trials. These drugs either have known anti-inflammatory action or inhibit the inflammatory response through unknown mechanisms. The results of these preclinical studies and clinical trials are reviewed. Recommendations are suggested on how to improve preclinical testing of drugs to make them more relevant to evaluate for clinical trials. (C) 2015 Elsevier Inc. All rights reserved.
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