4.5 Article

Levetiracetam in lactation: How much is excreted into human breast milk?

期刊

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
卷 88, 期 1, 页码 199-205

出版社

WILEY
DOI: 10.1111/bcp.14940

关键词

infant exposure; levetiracetam; breastfeeding women; breastmilk excretion; levetiracetam; levetiracetam safety in breastfeeding

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This study examined the excretion of levetiracetam in breastmilk in breastfeeding women with epilepsy, finding that exposure to the drug in breastmilk may lead to infant toxicities. The study also revealed a close correlation between levetiracetam dose, maternal serum concentration, and breastmilk levels. Further studies are needed to assess the short- and long-term safety of levetiracetam in breastfeeding infants.
Aims In breastfeeding women, anti-epileptic therapy can lead to infant toxicities, even with newer anti-epileptic drugs such as levetiracetam. This study assessed levetiracetam breastmilk excretion and its correlation with the maternal oral dose and serum concentrations. Methods Women with epilepsy treated with levetiracetam were recruited to this study and completed a questionnaire. Levetiracetam concentrations were determined in serial breastmilk samples (pre-dose to 12 h post-dose period) and in a single pre-dose maternal serum sample. Results Twenty breastfeeding women and 21 infants (one woman with twins; 16 fully and five partially breastfed infants) participated in this study. The trough breastmilk/serum ratio of levetiracetam was 0.98 +/- 0.20. The infant levetiracetam daily dose was 5.39 +/- 1.96 and 2.70 +/- 0.98 mg(.)kg(-1.)d(-1), and the relative infant dose (RID) was 13.8 +/- 3.1% and 6.9 +/- 1.6% in the fully and partially breastfed infants, respectively. Substantial correlations between the levetiracetam dose, maternal serum and breastmilk trough concentrations, and breastmilk AUC values were found. Three women reported somnolence in their fully breastfed infants, which resolved shortly after switching to partial breastfeeding. All the infants gained weight according to their age. Conclusions Infant levetiracetam exposure via the breastmilk was close to the safety thresholds (trough breastmilk/serum ratio slightly below 1, RID > 10% in fully breastfed infants), and infant somnolescence reports could be related to exposure of the infants to levetiracetam via breastmilk. Further studies are warranted to reveal the short- and long-term safety of levetiracetam in breastfeeding.

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