4.7 Article

ADEIP: an integrated platform of age-dependent expression and immune profiles across human tissues

期刊

BRIEFINGS IN BIOINFORMATICS
卷 22, 期 6, 页码 -

出版社

OXFORD UNIV PRESS
DOI: 10.1093/bib/bbab274

关键词

aging; tissue; expression; immune; SARS-CoV-2; human mesenchymal stem cells (hMSC)

资金

  1. National Natural Foundation of China [81870129]
  2. China National Grand S&T Special Project [2018ZX10733403]
  3. Huazhong Agricultural University

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Gene expression and immune status in human tissues change with aging. A platform named ADEIP has been developed to integrate age-dependent gene expression and immune profiles across tissues, providing a powerful tool for studying immune regulation in organogenesis and infectious or genetic diseases related to aging.
Gene expression and immune status in human tissues are changed with aging. There is a need to develop a comprehensive platform to explore the dynamics of age-related gene expression and immune profiles across tissues in genome-wide studies. Here, we collected RNA-Seq datasets from GTEx project, containing 16704 samples from 30 major tissues in six age groups ranging from 20 to 79 years old. Dynamic gene expression along with aging were depicted and gene set enrichment analysis was performed among those age groups. Genes from 34 known immune function categories and immune cell compositions were investigated and compared among different age groups. Finally, we integrated all the results and developed a platform named ADEIP (http://gb.whu.edu.cn/ADEIP or http://geneyun.net/ADEIP), integrating the age-dependent gene expression and immune profiles across tissues. To demonstrate the usage of ADEIP, we applied two datasets: severe acute respiratory syndrome coronavirus 2 and human mesenchymal stem cells-assoicated genes. We also included the expression and immune dynamics of these genes in the platform. Collectively, ADEIP is a powerful platform for studying age-related immune regulation in organogenesis and other infectious or genetic diseases.

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