期刊
BREAST CANCER RESEARCH AND TREATMENT
卷 189, 期 1, 页码 1-13出版社
SPRINGER
DOI: 10.1007/s10549-021-06291-8
关键词
Immunotherapy; Checkpoint inhibitors; Novel immunotherapeutic combinations; Hormone receptor-positive breast cancer
类别
While checkpoint inhibitors have shown benefit in PDL1-positive triple negative breast cancer, their efficacy in hormone receptor-positive, HER2-negative breast cancer remains limited. Combining immunotherapy with other treatments such as chemotherapy, endocrine therapy, and targeted agents may enhance anti-tumor activity in this subtype.
While checkpoint inhibitors have been approved in patients with newly metastatic PDL1-positive triple negative breast cancer, similar clinical benefit with immunotherapy alone or in combination with chemotherapy has not been observed in patients with hormone receptor-positive, HER2- negative breast cancer in the metastatic setting. However, in the ISPY2 trial, an increase in pathologic response has been observed with the addition of immunotherapy (+/- PARP inhibition) to chemotherapy compared to chemotherapy alone in patients with high-risk hormone receptor-positive, HER2- breast cancer. We review strategies to enhance the immunotherapeutic activity in this subtype of breast cancer, including combinations of checkpoint inhibition with chemotherapy, endocrine therapy, PARP inhibitors, HDAC inhibitors, CDK4/6 inhibitors, and radiotherapy. Combinations with agents targeting novel immunotherapeutic targets are also discussed. Though there remains an unmet need for immunotherapy approaches in patients with hormone-receptor positive breast cancer, there are a number of approaches that may lead to increased anti-tumor activity with immunotherapy in this tumor subtype.
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