期刊
BMC PEDIATRICS
卷 21, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12887-021-02775-0
关键词
Vitamin a deficiency; Sleep disturbances; Autism spectrum disorder; Autism symptoms
类别
资金
- National Nature Science of Foundation of China [81771223, 81770526]
- Key Projects of Guangdong Province [2018B030335001]
- Social and People's Livelihood Project of Chongqing Science and Technology Commission [cstc2018jscx-msybX0106]
- [2007030002]
Vitamin A deficiency and sleep disturbances are closely related to the core symptoms of ASD in children, with the interaction between sleep disturbances and VAD being associated with the severity of autism symptoms. Regular monitoring of sleep and VA levels may be beneficial for children with ASD.
Background Vitamin A deficiency (VAD) and sleep disturbances have been reported in children with autism spectrum disorder (ASD). The influence of vitamin A (VA) levels on sleep regulation and sleep disturbances in ASD has garnered concern. The present study aimed to characterize the association of VA levels with sleep disturbances in children with ASD. Methods This cross-sectional study compared children with ASD (n = 856) to typically developing children (TDC; n = 316). We used the Children's Sleep Habits Questionnaire to assess sleep disturbances, Childhood Autism Rating Scale to evaluate the severity of autism symptoms, and Autism Behavior Checklist and Social Responsiveness Scale to assess autism behaviors. Serum VA levels were estimated using high-performance liquid chromatography. Multivariable linear regression and two-way analysis of variance were performed to investigate if VAD was related to sleep disturbances in children with ASD. Results Children with ASD had lower serum VA levels and a higher prevalence of sleep disturbances than TDC did. The incidence of VAD in ASD children with sleep disturbances was higher, and the symptoms more severe than those without sleep disturbances and TDC. Interestingly, the interaction between VAD and sleep disturbances was associated with the severity of autism symptoms. Conclusion VAD and sleep disturbances are associated with the core symptoms of ASD in children. Regular monitoring of sleep and VA levels may be beneficial for children with ASD.
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