How hematopoietic stem/progenitors and their niche sense and respond to infectious stress

Hematopoietic stem/progenitor cells (HSPCs) play important roles in fighting systemic infection as they supply immune cells in a demand-adapted manner. Various mechanisms govern HSPC responses to infection, including cytokine signaling, niche function, and direct sensing of pathogen-derived molecules by HSPCs themselves. Here we review recent advances in our understanding of HSPC responses to infection and also consider newly identified STING mediated machinery recognizing bacteria-derived cyclic dinucleotides. Copyright (C) 2016 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc.