The association between mechanical ventilator compatible bed occupancy and mortality risk in intensive care patients with COVID-19: a national retrospective cohort study

Article Endocrinology & Metabolism

Type 2 Diabetes and COVID-19-Related Mortality in the Critical Care Setting: A National Cohort Study in England, March-July 2020

John M. Dennis et al.

Summary: The study showed that type 2 diabetes is a prognostic factor for survival in severe COVID-19 cases requiring critical care, with a higher risk of death for patients with diabetes, particularly in younger age groups.

DIABETES CARE (2021)

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Article Critical Care Medicine

Trends in Intensive Care for Patients with COVID-19 in England, Wales, and Northern Ireland

James C. Doidge et al.

Summary: The study described trends in intensive care for patients with COVID-19 and found significant variations in ICU admission rates during the first wave of the epidemic in England and Northern Ireland, varying over time and geography. Patient characteristics, care processes, and outcomes in ICU also changed, with some deviations in trends during the peak period. After adjusting for important risk factors, there was a substantial improvement in patient outcomes.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Medicine, General & Internal

Hospital bed capacity and usage across secondary healthcare providers in England during the first wave of the COVID-19 pandemic: a descriptive analysis

Bilal Akhter Mateen et al.

Summary: The study found that during the peak of the first wave of the COVID-19 pandemic, there was an adequate supply of all bed types across England, but unequal distribution of bed utilization led to many trusts operating above 'safe-occupancy' thresholds despite substantial capacity in geographically co-located trusts.

BMJ OPEN (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

Constantinos Kurt Wibmer et al.

Summary: The SARS-CoV-2 virus in the B.1.351 variant discovered in South Africa can evade neutralization by most antibodies when expressed, but does not affect binding by convalescent plasma. This suggests the potential for reinfection with antigenically distinct variants and predicts reduced efficacy of spike-based vaccines.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource

Angela Wood et al.

Summary: This study describes a novel England-wide electronic health record (EHR) resource for whole population research on covid-19 and cardiovascular disease, highlighting the importance of linking person level data across health settings to maximize completeness of key characteristics and to ascertain cardiovascular events and covid-19 diagnoses.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Critical Care Medicine

Trends in 28-Day Mortality of Critical Care Patients With Coronavirus Disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021

John M. Dennis et al.

Summary: During the peak of the second wave of COVID-19 in the UK (December 2020-January 2021), there was a marked deterioration in outcomes for patients admitted to critical care compared to the post-first-wave period (June 2020-September 2020). This increased mortality was independent of recorded patient characteristics and occupancy levels. Further research is needed to determine the extent to which this deterioration reflects the impact of the B117 variant of concern.

CRITICAL CARE MEDICINE (2021)

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Article Multidisciplinary Sciences

A national retrospective study of the association between serious operational problems and COVID-19 specific intensive care mortality risk

Harrison Wilde et al.

Summary: This study found a significant increase in mortality for COVID-19 patients admitted to ICU during periods of serious operational problems, indicating the need for further research to determine if this association could serve as a valid prognostic marker for deteriorating quality of care.

PLOS ONE (2021)

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Article Health Care Sciences & Services

The role of organizational characteristics on the outcome of COVID-19 patients admitted to the ICU in Belgium

Fabio Silvio Taccone et al.

Summary: The study in Belgium found that surge capacity organization, such as ICU overflow or the creation of COVID-19 specific supplementary ICU beds, negatively impacts the outcomes of critically ill COVID-19 patients admitted to ICUs.

LANCET REGIONAL HEALTH-EUROPE (2021)

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Letter Critical Care Medicine