期刊
BMC MEDICAL RESEARCH METHODOLOGY
卷 21, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12874-021-01371-1
关键词
Child; Neoplasms; Research design; Research personnel; Recruitment; Barriers
资金
- Children's Hospital Foundation
- Cancer Nurses Society Australia
- NHMRC Australia [APP1174733]
This study examines recruitment strategies and outcomes in multiple observational supportive care studies at a tertiary children's hospital. The research identifies factors influencing recruitment and provides principles to maximize recruitment and research findings' generalizability for future clinical research in pediatrics.
Background Variations in clinical practice contribute to negative outcomes for children with cancer. Research in this area is imperative to standardise practice, yet such research is challenging to undertake, and a significant proportion of studies fail. A common reason for failure is poor recruitment, yet little information is available to support researchers and clinicians planning such research. Methods Our primary aim was to describe the recruitment strategies and outcomes in a tertiary children's hospital across multiple observational supportive care studies. Secondary aims were to establish principles to improve both recruitment strategies and the reporting of recruitment. We undertook a retrospective descriptive analysis of the recruitment logs and data from three studies in pediatric oncology. The mean time to recruit one participant was calculated. Common reasons for not approaching eligible participants and reasons potential participants declined are described. Results Of the 235 potential candidates across all studies, 186 (79%) were approached and of these 125 (67%) provided consent, with 117 (63%) completing baseline measures. We estimated recruitment per participant required an average 98 min of experienced research nurse time. Four factors are described that influence recruitment and six principles are outlined to maximise recruitment and the generalisability of research findings. Conclusions We highlight the recruitment experiences across three different projects in children's cancer supportive care research and provide a roadmap for other researchers planning to undertake clinical research in pediatrics.
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