4.5 Article

Characterization of Salmonella serotypes prevalent in asymptomatic people and patients

期刊

BMC INFECTIOUS DISEASES
卷 21, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12879-021-06340-z

关键词

Salmonella; Asymptomatic infection; PFGE; Antimicrobial susceptibility

资金

  1. Jiangsu Key Laboratory of Zoonosis [R1703]
  2. Qing Lan Project of Yangzhou University
  3. National Natural Science Foundation of China [32072821]

向作者/读者索取更多资源

The study found that S. Typhimurium was the predominant serotype among Salmonella strains in Nantong city, China, with a high rate of multi-drug resistance. S. Enteritidis and S. Rissen were major serotypes among patients, while S. London, S. Derby, and S. Meleagridis were significant serotypes among asymptomatic people.
BackgroundInfection with Salmonella enterica usually results in diarrhea, fever, and abdominal cramps, but some people become asymptomatic or chronic carrier as a source of infection for others. This study aimed to analyze the difference in serotype, antimicrobial resistance, and genetic profiles between Salmonella strains isolated from patients and those from asymptomatic people in Nantong city, China.MethodsA total of 88 Salmonella strains were collected from patients and asymptomatic people from 2017 to 2018. Serotyping, antimicrobial susceptibility testing, and PFGE analysis were performed to analyze the characteristics of these strains.ResultsTwenty serotypes belonging to 8 serogroups were identified in the 88 Salmonella strains. S. Typhimurium remained to be the predominant serotype in strains from both patients and asymptomatic people. Among the 27 strains from patients, S. Enteritidis and S. Rissen were shown as the other two major serotypes, while S. London, S. Derby, and S. Meleagridis were demonstrated as the other significant serotypes among the 61 strains from asymptomatic people. Antimicrobial resistance testing revealed that 84.1% of strains from both resources were multi-drug resistant. PFGE displayed a highly discriminative ability to differentiate strains belonging to S. Derby, S. Typhimurium, etc., but could not efficiently differentiate serotypes like S. Enteritidis.ConclusionsThis study's results demonstrated that S. Typhimurium could cause human infection in both symptomatic and asymptomatic state; S. London, S. Derby, and S. Meleagridis usually cause asymptomatic infection, while S. Enteritidis infection mainly results in human diseases. The high multi-drug resistance rate detected in the antimicrobial resistance and diverse PFGE profiles of these strains implied that the strains were isolated from different sources, and the increased surveillance of Salmonella from both patients and asymptomatic people should be taken to control the disease.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据