Losing control to bad relatives

In this issue of Blood, Martin Merinero et al identified the mechanism of excessive complement activation caused by recurrent mutations in factor H-related protein-1 (FHR-1) in a few patients with atypical hemolytic uremic syndrome (aHUS). These are rare mutations in a rare disease, but the results provide a better understanding of complement regulation.(1)

Automated summary

This study identified the mechanism of excessive complement activation caused by recurrent mutations in FHR-1 in patients with aHUS, providing a better understanding of complement regulation in rare mutations in a rare disease.