期刊
BIOTECHNOLOGY ADVANCES
卷 54, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2021.107796
关键词
Child; Digestion; Gut physiology evolution; Gut microbiota; In vitro gut models; Nutrition; Pharmacy; Microbiology; Toxicology
This article reviews the development of child gut physiology and the use of in vitro models to study it. Research has shown that the child digestive tract undergoes significant changes in the first few years of life, including colonization of gut microbiota and exposure to environmental compounds. In vitro models are increasingly used due to ethical and technical limitations, and can simulate different stages of digestion from the oral phase to the colon compartment. These models have important applications in nutritional, pharmaceutical, and microbiological studies.
The human digestion is a multi-step and multi-compartment process essential for human health, at the heart of many issues raised by academics, the medical world and industrials from the food, nutrition and pharma fields. In the first years of life, major dietary changes occur and are concomitant with an evolution of the whole child digestive tract anatomy and physiology, including colonization of gut microbiota. All these phenomena are influenced by child exposure to environmental compounds, such as drugs (especially antibiotics) and food pollutants, but also childhood infections. Due to obvious ethical, regulatory and technical limitations, in vivo approaches in animal and human are more and more restricted to favor complementary in vitro approaches. This review summarizes current knowledge on the evolution of child gut physiology from birth to 3 years old regarding physicochemical, mechanical and microbial parameters. Then, all the available in vitro models of the child digestive tract are described, ranging from the simplest static mono-compartmental systems to the most sophisticated dynamic and multi-compartmental models, and mimicking from the oral phase to the colon compartment. Lastly, we detail the main applications of child gut models in nutritional, pharmaceutical and microbiological studies and discuss the limitations and challenges facing this field of research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据