MicroRNA-375: potential cancer suppressor and therapeutic drug

MiR-375 is a conserved noncoding RNA that is known to be involved in tumor cell proliferation, migration, and drug resistance. Previous studies have shown that miR-375 affects the epithelial-mesenchymal transition (EMT) of human tumor cells via some key transcription factors, such as Yes-associated protein 1 (YAP1), Specificity protein 1 (SP1) and signaling pathways (Wnt signaling pathway, nuclear factor kappa B (NE-kappa B) pathway and transforming growth factor beta (TGF-beta) signaling pathway) and is vital for the development of cancer. Additionally, recent studies have identified microRNA (miRNA) delivery system carriers for improved in vivo transportation of miR-375 to specific sites. Here, we discussed the role of miR-375 in different types of cancers, as well as molecular mechanisms, and analyzed the potential of miR-375 as a molecular biomarker and therapeutic target to improve the efficiency of clinical diagnosis of cancer.

Automated summary

MiR-375, a conserved noncoding RNA, plays a crucial role in tumor cell proliferation, migration, and drug resistance. Studies have shown that it affects the epithelial-mesenchymal transition of tumor cells through key transcription factors and signaling pathways, making it vital for cancer development. Recent research has also identified microRNA delivery systems for enhanced in vivo transportation of miR-375.