相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands
Luyu Fan et al.
NATURE COMMUNICATIONS (2020)
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane
Jie Yin et al.
NATURE (2020)
Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone
Dohyun Im et al.
NATURE COMMUNICATIONS (2020)
Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds
Ewgenij Proschak et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Second M3 muscarinic receptor binding site contributes to bronchoprotection by tiotropium
Loes E. M. Kistemaker et al.
BRITISH JOURNAL OF PHARMACOLOGY (2019)
Understanding Ligand Binding Selectivity in a Prototypical GPCR Family
Giulio Mattedi et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)
Aminergic GPCR-Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data
Marton Vass et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology
Yao Peng et al.
CELL (2018)
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
Sheng Wang et al.
NATURE (2018)
Negative symptoms of schizophrenia: new developments and unanswered research questions
Silvana Galderisi et al.
LANCET PSYCHIATRY (2018)
A comprehensive map of molecular drug targets
Rita Santos et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Computational polypharmacology: a new paradigm for drug discovery
Rajan Chaudhari et al.
EXPERT OPINION ON DRUG DISCOVERY (2017)
Structural Isosteres of Phosphate Groups in the Protein Data Bank
Yuezhou Zhang et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
Trends in GPCR drug discovery: new agents, targets and indications
Alexander S. Hauser et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Crystal Structure of an LSD-Bound Human Serotonin Receptor
Daniel Wacker et al.
CELL (2017)
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
David M. Thal et al.
NATURE (2016)
Isoindole-1,3-dione derivatives as RSK2 inhibitors: synthesis, molecular docking simulation and SAR analysis
Wei Zhou et al.
MEDCHEMCOMM (2016)
Generic GPCR residue numbers - aligning topology maps while minding the gaps
Vignir Isberg et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands?
Mayako Michino et al.
PHARMACOLOGICAL REVIEWS (2015)
The ChEMBL bioactivity database: an update
A. Patricia Bento et al.
NUCLEIC ACIDS RESEARCH (2014)
A convenient one-pot synthesis of polysubstituted pyrroles from N-protected succinimides
Marwan Kobeissi et al.
TETRAHEDRON LETTERS (2014)
Multiple Fragment Docking and Linking in Primary and Secondary Pockets of Dopamine Receptors
Marton Vass et al.
ACS MEDICINAL CHEMISTRY LETTERS (2014)
Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia
Uyen Le et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2013)
Structural Basis for Molecular Recognition at Serotonin Receptors
Chong Wang et al.
SCIENCE (2013)
Structural Features for Functional Selectivity at Serotonin Receptors
Daniel Wacker et al.
SCIENCE (2013)
Serial Femtosecond Crystallography of G Protein-Coupled Receptors
Wei Liu et al.
SCIENCE (2013)
Bridging the gap: bitopic ligands of G-protein-coupled receptors
J. Robert Lane et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2013)
Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors
Eva Agai-Csongor et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Multiple ligand docking by Glide: implications for virtual second-site screening
Marton Vass et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2012)
Discovery of a Series of 2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of Kv7.2 (KCNQ2) Channel Pharmacology: Identification of (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant Kv7.2 Channel Inhibitor
Yiu-Yin Cheung et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor
Amy Hauck Newman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Structure and dynamics of the M3 muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2012)
fconv: format conversion, manipulation and feature computation of molecular data
Gerd Neudert et al.
BIOINFORMATICS (2011)
Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H1 Receptor
Chris de Graaf et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Structure of the human histamine H1 receptor complex with doxepin
Tatsuro Shimamura et al.
NATURE (2011)
Pathway and mechanism of drug binding to G-protein-coupled receptors
Ron O. Dror et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT1A/B/D Receptor Antagonist
Colin P. Leslie et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist-Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile
Bela Kiss et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist
Ellen Y. T. Chien et al.
SCIENCE (2010)
Empirical Scoring Functions for Advanced Protein-Ligand Docking with PLANTS
Oliver Korb et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2009)
LSD-assisted psychotherapy in persons suffering from anxiety associated with advanced-stage life threatening diseases. A phase-II, double-blind, placebo-controlled dose-response pilot study
Torsten Passie et al.
CNS NEUROSCIENCE & THERAPEUTICS (2008)
The pipeline and future of drug development in schizophrenia
J. A. Gray et al.
MOLECULAR PSYCHIATRY (2007)
Optimizing fragment and scaffold docking by use of molecular interaction fingerprints
Gilles Marcou et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2007)
Research on adverse drug events.: I.: Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes
JS Silvestre et al.
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY (2005)
分享论文
