相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Novel tacrine-coumarin hybrids linked to 1,2,3-triazole as anti-Alzheimer's compounds: In vitro and in vivo biological evaluation and docking study
Zahra Najafi et al.
BIOORGANIC CHEMISTRY (2019)
Structure-based virtual screening leading to discovery of highly selective butyrylcholinesterase inhibitors with solanaceous alkaloid scaffolds
Shuo Zhou et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2019)
Synthesis, computational molecular docking analysis and effectiveness on tyrosinase inhibition of kojic acid derivatives
Gulsah Karakaya et al.
BIOORGANIC CHEMISTRY (2019)
Synthesis and biological evaluation of indoloquinoline alkaloid cryptolepine and its bromo-derivative as dual cholinesterase inhibitors
Vijay K. Nuthakki et al.
BIOORGANIC CHEMISTRY (2019)
Ageing as a risk factor for neurodegenerative disease
Yujun Hou et al.
NATURE REVIEWS NEUROLOGY (2019)
Efficacy and Safety of Cholinesterase Inhibitors for Mild Cognitive Impairment: A Systematic Review and Meta-Analysis
Shinji Matsunaga et al.
JOURNAL OF ALZHEIMERS DISEASE (2019)
Critical evaluation of current Alzheimer's drug discovery (2018-19) & futuristic Alzheimer drug model approach
Atukuri Dorababu
BIOORGANIC CHEMISTRY (2019)
New tacrine-acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease
Nina Chufarova et al.
ARCHIV DER PHARMAZIE (2018)
A molecular approach in drug development for Alzheimer's disease
Snezana Agatonovic-Kustrin et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections
Elisa Uliassi et al.
CHEMMEDCHEM (2018)
Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives
Joao Paulo Bizarro Lopes et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2018)
Alzheimer's Disease: Past, Present, and Future
Mark W. Bondi et al.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY (2017)
Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson's disease dementia
Nagaendran Kandiah et al.
CLINICAL INTERVENTIONS IN AGING (2017)
Hybrid Compounds as Direct Multitarget Ligands: A Review
Michelle de Oliveira Pedrosa et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2017)
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives
Serena Montanari et al.
CHEMMEDCHEM (2016)
Calculating protein-ligand binding affinities with MMPBSA: Method and error analysis
Changhao Wang et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2016)
1,2,3-Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV-1 Vif Antagonists
Idrees Mohammed et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
An efficient practical tosylation of phenols, amines, and alcohols employing mild reagent [DMAPT's]+Cl-
Chiranjeevi Dhonthulachitty et al.
TETRAHEDRON LETTERS (2016)
Chloroquine and Chloroquinoline Derivatives as Models for the Design of Modulators of Amyloid Peptide Precursor Metabolism
Patricia Melnyk et al.
ACS CHEMICAL NEUROSCIENCE (2015)
Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses
Oksana Lockridge
PHARMACOLOGY & THERAPEUTICS (2015)
Solanocapsine derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies
Manuela E. Garcia et al.
STEROIDS (2015)
Status of Acetylcholinesterase and Butyrylcholinesterase in Alzheimer's Disease and Type 2 Diabetes Mellitus
Gohar Mushtaq et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2014)
A review on cholinesterase inhibitors for Alzheimer's disease
Preet Anand et al.
ARCHIVES OF PHARMACAL RESEARCH (2013)
Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase
Florian Nachon et al.
BIOCHEMICAL JOURNAL (2013)
Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection
Manjinder Singh et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Structure-Based Search for New Inhibitors of Cholinesterases
Marek Bajda et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)
Automated Docking with Protein Flexibility in the Design of Femtomolar Click Chemistry Inhibitors of Acetylcholinesterase
Garrett M. Morris et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2013)
Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease
Rafael Leon et al.
MEDICINAL RESEARCH REVIEWS (2013)
Huprine-Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer's and Prion Diseases
Caries Galdeano et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
H++3.0: automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations
Ramu Anandakrishnan et al.
NUCLEIC ACIDS RESEARCH (2012)
Active Site Gating and Substrate Specificity of Butyrylcholinesterase and Acetylcholinesterase: Insights from Molecular Dynamics Simulations
Lei Fang et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2011)
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates
Pelayo Camps et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Acetylcholinesterase: From 3D structure to function
Hay Dvir et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Conformer Generation with OMEGA: Algorithm and Validation Using High Quality Structures from the Protein Databank and Cambridge Structural Database
Paul C. D. Hawkins et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2010)
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation
Pelayo Camps et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Applications of N-chlorosuccinimide in organic synthesis
W. Marek Golebiewski et al.
SYNTHESIS-STUTTGART (2007)
Comparison of topological, shape, and docking methods in virtual screening
Georgia B. McGaughey et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2007)
Probing polar solvation dynamics in proteins: A molecular dynamics simulation analysis
Andrei A. Golosov et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2007)
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase:: Binding of bis(5)-tacrine produces a dramatic rearrangement in the active-site gorge
Edwin H. Rydberg et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
A simple clustering algorithm can be accurate enough for use in calculations of pKs in macromolecules
Jonathan Myers et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE
D Alonso et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Scalable molecular dynamics with NAMD
JC Phillips et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors:: New disease-modifying agents for Alzheimer's disease
P Muñoz-Ruiz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
In situ selection of lead compounds by click chemistry: Target-guided optimization of acetylcholinesterase inhibitors
A Krasinski et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors
G Campiani et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Bis-huperzine B: Highly potent and selective acetylcholine sterase inhibitors
S Feng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Synthesis and characterization of the 7-(4-aminomethyl-1H-1,2,3-triazol-1-yl) analogue of kabiramide C
C Petchprayoon et al.
JOURNAL OF NATURAL PRODUCTS (2005)
Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease
C Geula et al.
DRUGS OF TODAY (2004)
Development and testing of a general amber force field
JM Wang et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation:: A dual function lead for Alzheimer's disease therapy
L Piazzi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Gaussian docking functions
MR McGann et al.
BIOPOLYMERS (2003)
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 Å resolution:: Kinetic and molecular dynamic correlates
H Dvir et al.
BIOCHEMISTRY (2002)
Advances in the treatment of Alzheimer's disease: Benefits of dual cholinesterase inhibition
CG Ballard
EUROPEAN NEUROLOGY (2002)
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase
L Savini et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
Calculating structures and free energies of complex molecules: Combining molecular mechanics and continuum models
PA Kollman et al.
ACCOUNTS OF CHEMICAL RESEARCH (2000)
分享论文
