期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 43, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2021.128104
关键词
Twin insecticides; Botanical bioactive product; Insecticidal activity; Podophyllum hexandrum; Thermopsis lanceolata
资金
- National Natural Science Foundation of China [31872013]
Researchers prepared a series of twin compounds from podophyllotoxin and cytisine isolated from Podophyllum hexandrum and Thermopsis lanceolata, some of which exhibited potent insecticidal activity, suggesting a new direction for botanical pesticide research.
To explore natural-product-based insecticide candidates, and high value-added application of natural plants in agriculture, a series of twin compounds were prepared from two natural products podophyllotoxin and cytisine, which are isolated from the plants Podophyllum hexandrum and Thermopsis lanceolata, respectively. Compounds IIa (X = Cl, Y = R1 = R2 = H), IIIc (X = Y = R1 = R2 = Cl) and IVd (X = R1 = R2 = Br, Y = H) exhibited >2-fold potent insecticidal activity of podophyllotoxin against armyworm with FMRs greater than 60%. SARs were also observed. It is noteworthy that the idea of twin insecticides was addressed for the first time. We hope this idea will be conducive to design new twin insecticidal agents, and lay the foundation for future high value-added application of the plants P. hexandrum and T. lanceolata as potentially botanical pesticides in agriculture.
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