相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Employing Photocatalysis for the Design and Preparation of DNA-encoded Libraries: A Case Study
Dominik K. Kolmel et al.
CHEMICAL RECORD (2021)
Trends in Hit-to-Lead Optimization Following DNA-Encoded Library Screens
Christopher A. Reiher et al.
ACS MEDICINAL CHEMISTRY LETTERS (2021)
Functionalization of DNA-Tagged Alkenes Enabled by Visible-Light-Induced C-H Activation of N-Aryl Tertiary Amines
Rongfeng Wu et al.
ORGANIC LETTERS (2021)
High Fidelity Suzuki-Miyaura Coupling for the Synthesis of DNA Encoded Libraries Enabled by Micelle Forming Surfactants
James H. Hunter et al.
BIOCONJUGATE CHEMISTRY (2020)
C-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis
Ying-Chu Chen et al.
BIOCONJUGATE CHEMISTRY (2020)
DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors
Wieslaw M. Kazmierski et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins
Justin M. Rectenwald et al.
MOLECULES (2020)
Synthesis of Multifunctional 2-Aminobenzimidazoles on DNA via Iodine-Promoted Cyclization
Liqiang Su et al.
ORGANIC LETTERS (2020)
Selection of DNA-Encoded Dynamic Chemical Libraries for Direct Inhibitor Discovery
Yuqing Deng et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)
Reaction development for DNA-encoded library technology: From evolution to revolution?
Katharina Goette et al.
TETRAHEDRON LETTERS (2020)
Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library
Pei-Pei Kung et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries
Doris Mia Taylor et al.
ACS INFECTIOUS DISEASES (2020)
TEAD-YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics
Verena B. K. Kunig et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)
Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry
John W. Cuozzo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Navigating the DNA encoded libraries chemical space
Alfredo Martin et al.
COMMUNICATIONS CHEMISTRY (2020)
A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes
Lik Hang Yuen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
A Mild, DNA-Compatible Nitro Reduction Using B2(OH)4
Huang-Chi Du et al.
ORGANIC LETTERS (2019)
A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles
Cedric J. Stress et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Functionality-Independent DNA Encoding of Complex Natural Products
Peixiang Ma et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support
Dillon T. Flood et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry
Alexander Litovchick et al.
MOLECULES (2019)
Micellar Bronsted Acid Mediated Synthesis of DNA-Tagged Heterocycles
M. Klika Skopic et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
DNA Barcoding a Complete Matrix of Stereoisomeric Small Molecules
Christopher J. Gerry et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Application of a Substrate-Mediated Selection with c-Src Tyrosine Kinase to a DNA-Encoded Chemical Library
Dongwook Kim et al.
MOLECULES (2019)
DNA-Encoded Combinatorial Library of Macrocyclic Peptoids
Min Hyeon Shin et al.
BIOCONJUGATE CHEMISTRY (2019)
Designing DNA Encoded Libraries of Diverse Products in a Focused Property Space
Hongyao Zhu et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)
Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection
David A. DeGoey et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Making molecular monsters
Michelle Francl
NATURE CHEMISTRY (2018)
A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition
Nicholas Favalli et al.
CHEMMEDCHEM (2018)
Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules
Dmitry L. Usanov et al.
NATURE CHEMISTRY (2018)
What Do You Get from DNA-Encoded Libraries?
Alexander L. Satz
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Development and Synthesis of DNA-Encoded Benzimidazole Library
Yun Ding et al.
ACS COMBINATORIAL SCIENCE (2018)
DNA-Compatible Solid-Phase Combinatorial Synthesis of β-Cyanoacrylamides and Related Electrophiles
Kevin Pels et al.
ACS COMBINATORIAL SCIENCE (2018)
DNA-Encoded Dynamic Chemical Library and Its Applications in Ligand Discovery
Yu Zhou et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Design and Application of a DNA-Encoded Macrocyclic Peptide Library
Zhengrong Zhu et al.
ACS CHEMICAL BIOLOGY (2018)
DNA-encoded chemistry: enabling the deeper sampling of chemical space
Robert A. Goodnow et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Acid- and Au(I)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures
Mateja Klika Skopic et al.
CHEMICAL SCIENCE (2017)
On-DNA Pd and Cu promoted C-N cross-coupling reactions
Xiaojie Lu et al.
MEDCHEMCOMM (2017)
Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action
Amaury E. Fernandez-Montalvan et al.
ACS CHEMICAL BIOLOGY (2017)
Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library
John W. Cuozzo et al.
CHEMBIOCHEM (2017)
Discovering Drugs with DNA-Encoded Library Technology: From Concept to Clinic with an Inhibitor of Soluble Epoxide Hydrolase
Svetlana L. Belyanskaya et al.
CHEMBIOCHEM (2017)
Zirconium(IV)-Catalyzed Ring Opening of on-DNA Epoxides in Water
Lijun Fan et al.
CHEMBIOCHEM (2017)
Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
Dean G. Brow et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors
Philip A. Harris et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Novel p38 alpha MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library
L. K. Petersen et al.
MEDCHEMCOMM (2016)
Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold
M. Klika Skopic et al.
MEDCHEMCOMM (2016)
Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors
Hongfeng Deng et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
What is a DNA-Compatible Reaction?
Marie L. Malone et al.
ACS COMBINATORIAL SCIENCE (2016)
Identification of Structure-Activity Relationships from Screening a Structurally Compact DNA-Encoded Chemical Library
Raphael M. Franzini et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Encoded Library Technology Screening of Hepatitis C Virus NS4B Yields a Small-Molecule Compound Series with In Vitro Replicon Activity
Christopher Arico-Muendel et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity
Benjamin A. Seigal et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)
Hongfang Yang et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT)
Yun Ding et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library
Hongfeng Deng et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor
Zining Wu et al.
ACS COMBINATORIAL SCIENCE (2015)
Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library
Alexander Litovchick et al.
SCIENTIFIC REPORTS (2015)
A DNA-templated synthesis of encoded small molecules by DNA self-assembly
Cheng Cao et al.
CHEMICAL COMMUNICATIONS (2014)
Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
Bradley Croy Doak et al.
CHEMISTRY & BIOLOGY (2014)
Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA
Lourdes Encinas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Estimation of the size of drug-like chemical space based on GDB-17 data
P. G. Polishchuk et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)
Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library
Markus Leimbacher et al.
CHEMISTRY-A EUROPEAN JOURNAL (2012)
Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)
Hongfeng Deng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds
Fabian Buller et al.
ACS CHEMICAL BIOLOGY (2011)
Principles of early drug discovery
J. P. Hughes et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Molecular complexity and fragment-based drug discovery: ten years on
Andrew R. Leach et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2011)
The Medicinal Chemist's Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
Stephen D. Roughley et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Isolation of Potent and Specific Trypsin Inhibitors from a DNA-Encoded Chemical Library
Luca Mannocci et al.
BIOCONJUGATE CHEMISTRY (2010)
Isolation of a Small-Molecule Inhibitor of the Antiapoptotic Protein Bcl-xL from a DNA-Encoded Chemical Library
Samu Melkko et al.
CHEMMEDCHEM (2010)
Discovery of TNF Inhibitors from a DNA-Encoded Chemical Library based on Diels-Alder Cycloaddition
Fabian Buller et al.
CHEMISTRY & BIOLOGY (2009)
A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution
Margit Haahr Hansen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Design, synthesis and selection of DNA-encoded small-molecule libraries
Matthew A. Clark et al.
NATURE CHEMICAL BIOLOGY (2009)
Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions
Fabian Buller et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Translation of DNA into a Library of 13 000 Synthetic Small-Molecule Macrocycles Suitable for in Vitro Selection
Brian N. Tse et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries
Luca Mannocci et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Synthetic ligands discovered by in vitro selection
S. Jarrett Wrenn et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
DNA-templated organic synthesis and selection of a library of macrocycles
ZJ Gartner et al.
SCIENCE (2004)
Encoded self-assembling chemical libraries
S Melkko et al.
NATURE BIOTECHNOLOGY (2004)
Molecular complexity and its impact on the probability of finding leads for drug discovery
MM Hann et al.
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES (2001)
Diversity screening versus focussed screening in drug discovery
MJ Valler et al.
DRUG DISCOVERY TODAY (2000)
分享论文
